Results 181 to 190 of about 113,588 (316)

Extracellular RNAs in Liquid Biopsy: Applications in MASLD and MASH Diagnosis and Monitoring. [PDF]

Diagnostics (Basel)
Raptis D, Kolli ST, Agarwal S, Komminni PK, Bhattarai P, Hablani P, Kumar R, Das P, McIntosh M, Kladas M, Gokulnath P, Spanos M.   +11 more
europepmc   +1 more source

One‐Step Drug Screening System Utilizing Electrophysiological Activity in Multiple Brain Organoids

Advanced Science, EarlyView.
This study presents a one‐step system that delivers different drug doses to brain organoids and monitors their neural activity using integrated 3D microelectrodes. By combining dose‐specific microfluidic delivery with high‐resolution electrophysiological recording, the platform enables simultaneous, real‐time screening of neural responses across ...
Hyogeun Shin, Yeonjoo An, Ju‐Hyun Lee, Ji Hun Kim, Renuka Prasad, Keun‐Tae Kim, Hoon‐Chul Kang, Woong Sun, Seung‐Woo Cho, Il‐Joo Cho   +9 more
wiley   +1 more source

Automated Single-Cell Analysis in the Liquid Biopsy of Breast Cancer. [PDF]

Cancers (Basel)
Shishido SN, Courcoubetis G, Kuhn P, Mason J.   +3 more
europepmc   +1 more source

From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies

Advanced Science, EarlyView.
This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen, Ran Ren, Lirong Yan, Yu Zhou, Ruokai Sun, Huicong Song, Hongfei Yan, Yongsheng Li   +7 more
wiley   +1 more source

Estrogen receptor mutations and splice variants determined in liquid biopsies from metastatic breast cancer patients [PDF]

, 2017
Nick Beije, Anieta M. Sieuwerts, Jaco Kraan, Ngoc M. Van, Wendy Onstenk, Silvia Rita Vitale, Michelle van der Vlugt‐Daane, Luc Dirix, Anja Brouwer, Paul Hamberg, Felix E. de Jongh, Agnes Jager, Caroline Seynaeve, Maurice P.H.M. Jansen, John A. Foekens, John W.M. Martens, Stefan Sleijfer   +16 more
openalex   +1 more source

Prognostic Significance of Liquid Biopsy-Detected Genetic Alterations in Hepatocellular Carcinoma. [PDF]

J Hepatocell Carcinoma
Sarıtaş AG, Yavuz B, Aydın İ, Ağca H, Topal U, Ballı T, Bisgin A, Ülkü A, Akçam AT.   +8 more
europepmc   +1 more source

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source

Liquid biopsies in lung cancer—time to implement research technologies in routine care? [PDF]

, 2017
Linda M. Kohn, Mikael Johansson, Kjell Grankvist, Jonas Nilsson   +3 more
openalex   +1 more source

Advances in liquid biopsy for bone and soft-tissue sarcomas. [PDF]

Int J Clin Oncol
Wang Y, Fujiwara T, Kurozumi T, Ando T, Ishimaru T, Kondo H, Nakata E, Kunisada T, Ozaki T.   +8 more
europepmc   +1 more source

APOL2 Stabilizes Ku80 to Confer NHEJ‐Mediated Radioresistance in Gastric Cancer

Advanced Science, EarlyView.
Radiotherapy resistance in gastric cancer (GC) is often mediated by enhanced DNA repair. APOL2 is found to promote NHEJ by stabilizing Ku80, conferring radioresistance. High APOL2 correlates with poor prognosis. Formononetin disrupts APOL2‐Ku80, restoring radiosensitivity, suggesting a novel therapeutic strategy.
Dan Zu, Qimei Bao, Hanyi He, Yuke Zhong, Mingcong Deng, Yangchan Hu, Chunkai Zhang, Chen Liang, Yixing Huang, Haidong Liu, Xiao Li, Yanhua He, Guoyan Luo, Weixin Wu, Fenghui Guan, Shengfeng Xu, Min Liu, Albino Bacolla, Ji Jing, Yian Du, John A. Tainer, Yin Shi, Zu Ye, Xiangdong Cheng   +23 more
wiley   +1 more source