Results 161 to 170 of about 194,004 (300)

Editorial: Emerging Biomarkers in Genitourinary Tumors [PDF]

, 2019
Cheng, Liang, Cimadamore, Alessia, Lopez-Beltran, Antonio, Montironi, Rodolfo, Santoni, Matteo   +4 more
core   +2 more sources

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

[Liquid biopsy].

Medicina, 2016
openaire   +3 more sources

A Multiomic Liquid Biopsy for the Earlier Detection of Colorectal Cancer. [PDF]

Cancer Prev Res (Phila)
Cameron JM, McHardy RG, Sala A, Butler HJ, Palmer DS, Mitchell PJ, Parkin E, Moug S, Baker MJ.   +8 more
europepmc   +1 more source

Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo‐Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men

Advanced Science, EarlyView.
In a randomized clinical trial, we test the potential of combined nicotinamide (NAM) and pyridoxine (PN) to improve muscle recovery through muscle stem cell (MuSC) activity. Daily oral NAM and PN supplementation after high intensity muscle contractions enhances MuSC activation and differentiation, and accelerates muscle regeneration, providing new ...
Grith Højfeldt, Joris Michaud, Ann Damgaard, Karoline Karlog, Eugenia Migliavacca, Sonia Karaz, Elham Pazirandeh‐Micol, Odd E. Johansen, Leonidas G. Karagounis, Bjørk W. Helge, William Hagemann, Michael Kjaer, Jerome N. Feige, Pascal Stuelsatz, Abigail L. Mackey   +14 more
wiley   +1 more source

Lexicon for Clonal Hematopoiesis in Liquid Biopsy. [PDF]

Clin Transl Sci
Tell R, Zehir A, Anfora AT, Basu G, Beidelschies M, Compton C, Cristiano S, Godsey JH, Hu J, Johann DJ, Juntilla M, Kansal R, Lo C, Lopez Ramos D, Mahaganapathy V, Merriam D, Rolfo C, Russell H, Singh U, Stetson D, You M, Leiman LC.   +21 more
europepmc   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Cancer in a Drop: Liquid biopsy insights from AACR 2025

The Journal of Liquid Biopsy
Shivahamy Maheswaran, Roberto Borea, Diego de Miguel Perez, Pasquale Pisapia, Nadia Ghazali, Canio Martinelli, Pavel Stejskal, Carolina Reduzzi   +7 more
doaj   +1 more source

Why the Therapeutic Impact of RAS Mutation Clearance in Plasma ctDNA Deserves to Be Further Explored in Metastatic Colorectal Cancer

Frontiers in Oncology, 2019
Chiara Nicolazzo, Francesca Belardinilli, Salvatore Caponnetto, Angela Gradilone, Enrico Cortesi, Giuseppe Giannini, Giuseppe Giannini, Paola Gazzaniga   +7 more
doaj   +1 more source

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source