Results 191 to 200 of about 3,019,224 (363)

Microphysiological Uremia Model Reveals Biophysical Potentiators of Vascular Dysfunction

Advanced Science, EarlyView.
A microfluidic platform of engineered blood vessels is developed to study the role of mechanical forces in immune cell adhesion and extravasation in uremic microenvironments. Elevated pressure increases monocyte activity, with ICAM‐1 as a key driver. Matrix density influences monocyte phenotypes, but the uremic environment consistently promoted a pro ...
Mitesh Rathod, Ryan N. Stack, Sarah E. Kubik, Stephanie A. Huang, Chloe P. Whitworth, Wen Y. Aw, Elizabeth L. Doherty, Sara M. Meehan, Prabir Roy‐Chaudhury, William J. Polacheck   +9 more
wiley   +1 more source

Liquid biopsy in lung cancer. [PDF]

Breathe (Sheff)
Toland S, Ridge P, O'Brien E, Morgan R, Toomey S, Hennessy BT, Ryan DJ.   +6 more
europepmc   +1 more source

Vesicle-MaNiA: extracellular vesicles in liquid biopsy and cancer

, 2016
Verónica Torrano, Félix Royo, Héctor Peinado, Ana Loizaga‐Iriarte, Miguel Unda, Juan Manuel Falcón‐Pérez, Arkaitz Carracedo   +6 more
openalex   +2 more sources

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

The potential of liquid biopsies for the early detection of cancer [PDF]

, 2017
Ellen Heitzer, Samantha Perakis, Jochen B. Geigl, Michael R. Speicher   +3 more
openalex   +1 more source

Advanced Microfluidics for Single Cell‐Based Cancer Research

Advanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro, Marta Aranda Palomer, Margarida Esteves, Carolina Rodrigues, José Maria Fernandes, Francisca Oliveira, Alexandra Teixeira, Carlos Honrado, Lorena Dieguez, Sara Abalde‐Cela, Miguel Xavier   +10 more
wiley   +1 more source

Liquid Biopsy in Lung Cancer: A Perspective From Members of the Pulmonary Pathology Society

, 2016
Lynette M. Sholl, Dara L. Aisner, Timothy Craig Allen, Mary Beth Beasley, Philip T. Cagle, Vera Luíza Capelozzi, Sanja Đačić, Lida P. Hariri, Keith M. Kerr, Sylvie Lantuéjoul, Mari Mino‐Kenudson, Kirtee Raparia, Natasha Rekhtman, Sinchita Roy‐Chowdhuri, Eric Thunnissen, Ming‐Sound Tsao, Marina Vivero, Yasushi Yatabe   +17 more
openalex   +1 more source

Saliva Liquid Biopsy for Point-of-Care Applications [PDF]

, 2017
Katri Aro, Wei Fang, David T. Wong, Michael Tu   +3 more
openalex   +1 more source

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Prediction of exosomal miRNA-based biomarkers for liquid biopsy. [PDF]

Sci Rep
Arora A, Raghava GPS.
europepmc   +1 more source