Results 1 to 10 of about 403,538 (154)

Development and validation of ultra‐high‐performance liquid chromatography–mass spectrometry method for the determination of raloxifene and its phase II metabolites in plasma: Application to pharmacokinetic studies in rats [PDF]

Journal of Separation Science, 2020
AbstractThe aim of this study is to establish a reliable liquid chromatography–mass spectrometry method to simultaneously quantitate raloxifene, and its major metabolites, raloxifene‐6‐glucuronide, raloxifene‐4′‐glucuronide, and raloxifene‐6‐sulfate in rat plasma samples for pharmacokinetic studies.
Ting Du, Rongjin Sun, Li Li, Christabel Ebuzoeme, Dinh Bui, Zicong Zheng, Taijun Yin, Dong Liang, Ming Hu, Song Gao   +9 more
openaire   +4 more sources

Chemical Composition of Leaves, Stem, and Roots of Peperomia pellucida (L.) Kunth

Molecules, 2022
Peperomia pellucida is a species known in the Amazon as “erva-de-jabuti” that has been used in several therapeutic applications based on folk medicine.
Paulo Wender P. Gomes, Hugo Barretto, José Diogo E. Reis, Abraão Muribeca, Alice Veloso, Carlos Albuquerque, Andrew Teixeira, Wandson Braamcamp, Sônia Pamplona, Consuelo Silva, Milton Silva   +10 more
doaj   +1 more source

Putative Identification of New Phragmaline-Type Limonoids from the Leaves of Swietenia macrophylla King: A Case Study Using Mass Spectrometry-Based Molecular Networking

Molecules, 2023
Swietenia macrophylla King is a plant commonly known as Brazilian mahogany. The wood from its stem is highly prized for its exceptional quality, while its leaves are valued for their high content of phragmalin-type limonoids, a subclass of compounds ...
José Diogo E. Reis, Paulo Wender P. Gomes, Paulo R. da C. Sá, Sônia das G. S. R. Pamplona, Consuelo Yumiko Y. e Silva, Maria Fátima das G. F. da Silva, Anupam Bishayee, Milton Nascimento da Silva   +7 more
doaj   +1 more source

Antiviral Plants from Marajó Island, Brazilian Amazon: A Narrative Review

Molecules, 2022
Diseases caused by viruses are a global threat, resulting in serious medical and social problems for humanity. They are the main contributors to many minor and major outbreaks, epidemics, and pandemics worldwide.
Paulo Wender P. Gomes, Luiza Martins, Emilli Gomes, Abraão Muribeca, Sônia Pamplona, Andrea Komesu, Carissa Bichara, Mahendra Rai, Consuelo Silva, Milton Silva   +9 more
doaj   +1 more source

Gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry metabolomics platforms: Tools for plant oligosaccharides analysis

Carbohydrate Polymer Technologies and Applications, 2023
Oligosaccharides play a central role in plants and are involved in basal metabolism, and many other functions at cellular levels. Indeed, oligosaccharides analysis was stimulated by the development of analytical chemistry and computational biology and ...
Noureddine Benkeblia
doaj   +1 more source

Pitfall in the high-throughput quantification of whole blood cyclosporin A using liquid chromatography-tandem mass spectrometry [PDF]

, 2005
In a growing number of laboratories the technique of liquid chromatography-tandem mass spectrometry is used for the quantification of cyclosporin A in whole blood, employing cyclosporin D as the internal standard. Cyclosporin A is extensively metabolized
Spöhrer, Ute, Vogeser, Michael
core   +2 more sources

Anti-High Mobility Group Box-1 Monoclonal Antibody Attenuates Seizure-Induced Cognitive Decline by Suppressing Neuroinflammation in an Adult Zebrafish Model

Frontiers in Pharmacology, 2021
Epilepsy is a chronic brain disease afflicting around 70 million global population and is characterized by persisting predisposition to generate epileptic seizures.
Yam Nath Paudel, Iekhsan Othman, Iekhsan Othman, Mohd. Farooq Shaikh   +3 more
doaj   +1 more source

Characterization of volatile thiols in Chinese liquor (Baijiu) by ultraperformance liquid chromatography–mass spectrometry and ultraperformance liquid chromatography–quadrupole-time-of-flight mass spectrometry

Frontiers in Nutrition, 2022
Volatile thiols give a unique flavor to foods and they have been extensively studied due to their effects on sensory properties. The analytical assay of volatile thiols in food is hindered by the complexity of the matrix, and by both their high ...
Yan Yan, Yan Yan, Jun Lu, Yao Nie, Changwen Li, Shuang Chen, Yan Xu   +6 more
doaj   +1 more source

Liquid chromatography and liquid chromatography-mass spectrometry analysis of donepezil degradation products [PDF]

Chemical Industry and Chemical Engineering Quarterly, 2015
This study describes the investigation of degradation products of donepezil (DP) using stability indicating RP-HPLC method for determination of donepezil, which is a centrally acting reversible acetylcholinesterase inhibitor.
Mladenović Aleksandar R., Jadranin Milka B., Pavlović Aleksandar D., Petrović Slobodan D., Drmanić Saša Ž., Avramov-Ivić Milk L., Mijin Dušan Ž.   +6 more
doaj   +1 more source

A Systematic Review of the Protective Actions of Cat’s Whiskers (Misai Kucing) on the Central Nervous System

Frontiers in Pharmacology, 2020
Orthosiphon stamineus (OS) or Orthosiphon aristatus var. aristatus (OAA) is commonly known as cat’s whiskers or “misai kucing”. It is an herbaceous shrub that is popular in many different traditional and complementary medicinal systems.
Yin-Sir Chung, Yin-Sir Chung, Brandon Kar Meng Choo, Pervaiz Khalid Ahmed, Pervaiz Khalid Ahmed, Iekhsan Othman, Iekhsan Othman, Mohd. Farooq Shaikh   +7 more
doaj   +1 more source