Predict potential pharmacological mechanisms of Ling-gui-Zhu-gan Decoction in treating unstable angina pectoris using liquid chromatography-mass spectrometry and network pharmacology. [PDF]
Li X +8 more
europepmc +1 more source
Photosensitizing lipid nanoparticles (PLNPs) are engineered by incorporating cholesterol–PEG–pheophorbide a into MC3‐based LNPs and encapsulating GPX4‐targeting siRNA. Upon light activation, PLNPs generate reactive oxygen species (ROS) while silencing GPX4 to induce ferroptosis.
Ga‐Hyun Bae +9 more
wiley +1 more source
Mechanism of total saponins of <i>Ranunculus ternatus</i> Thunb. in treatment of breast cancer based on liquid chromatography-mass spectrometry and network analysis. [PDF]
Zhang Y +5 more
europepmc +1 more source
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche +8 more
wiley +1 more source
Charge Variants Characterization of Co-Formulated Antibodies by Three-Dimensional Liquid Chromatography-Mass Spectrometry. [PDF]
Jin X, Chen L, Chu J, He B.
europepmc +1 more source
Synthetic Aspects and Characterization Needs in MOF Chemistry – from Discovery to Applications
Overcoming the challenges of phase discovery, synthesis optimization and scale‐up, characterization, and computational studies is essential to accelerate the large‐scale application of MOFs. Life‐cycle analyses and techno‐economic analyses need to be performed to realistically assess their potential for industrial relevance.
Bastian Achenbach +4 more
wiley +1 more source
Combined Quantification and Characterization of Dissolved Organic Matter by Liquid Chromatography-Mass Spectrometry Using Charged Aerosol Detection. [PDF]
Felgate SL +4 more
europepmc +1 more source
State‐of‐the‐Art, Insights, and Perspectives for MOFs‐Nanocomposites and MOF‐Derived (Nano)Materials
Different approaches to MOF‐NP composite formation, such as ship‐in‐a‐bottle, bottle‐around‐the‐ship and in situ one‐step synthesis, are used. Owing to synergistic effects, the advantageous features of the components of the composites are beneficially combined, and their individual drawbacks are mitigated.
Stefanos Mourdikoudis +6 more
wiley +1 more source

