Results 81 to 90 of about 722,813 (296)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

An optimized analytical method for the simultaneous detection of iodoform, iodoacetic acid, and other trihalomethanes and haloacetic acids in drinking water [PDF]

, 2013
An optimized method is presented using liquid-liquid extraction and derivatization for the extraction of iodoacetic acid (IAA) and other haloacetic acids (HAA9) and direct extraction of iodoform (IF) and other trihalomethanes (THM4) from drinking water ...
He, G, Jiang, S, Liu, X, Qu, W, Templeton, MR, Wei, X, Zheng, W   +6 more
core   +3 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Determining the distribution of triclosan and methyl triclosan in estuarine settings [PDF]

, 2014
We have developed a method for the analysis of two sewage-derived contaminants: triclosan (TCS), an antibacterial agent, and methyl triclosan (MTCS), a TCS metabolite.
Agüera, Azzouz, Balmer, Baltussen, Beltran, Bester, Buth, Canosa, Canosa, Cantwell, Casas-Ferreira, Chen, Chu, Cottell, Cueva-Mestanza, Eduardo González-Mazo, El Rayis, Fernandes, Fiss, Gilart, Giordano, Göbel, Heidler, Kantiani, Kawaguchi, Kuster, Lara-Martín, Lara-Martín, Lara-Martín, Lindström, Lozano, Marina G. Pintado-Herrera, Miller, Pablo A. Lara-Martín, Pedrouzo, Petrovic, Prieto, Pérez-Carrera, Quintana, Silva, Sánchez-Brunete, Ternes, Wu, Zaroogian, Zhao   +44 more
core   +2 more sources

Analytical and Clinical Performance of a Liquid Chromatography–Tandem Mass Spectrometry Method for Measuring Gastrin Subtypes G34 and G17 in Serum [PDF]

, 2021
Songlin Yu, Danchen Wang, Xiaoli Ma, Yuanyuan Zhang, Dandan Sun, Yutong Zou, Jialei Yu, Fang Zhang, Guohua Yang, Shaowei Xie, Qian Cheng, Xinqi Cheng, Ling Qiu   +12 more
openalex   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Determination of Flavonoid Glycosides by UPLC-MS to Authenticate Commercial Lemonade

Molecules, 2019
So far, there is no report on the quality evaluation of lemonade available in the market. In this study, a sample preparation method was developed for the determination of flavonoid glycosides by ultra-performance liquid chromatography−mass ...
Ying Xue, Lin-Sen Qing, Li Yong, Xian-Shun Xu, Bin Hu, Ming-Qing Tang, Jing Xie   +6 more
doaj   +1 more source

Identification of Trenbolone Metabolites Using Hydrogen Isotope Ratio Mass Spectrometry and Liquid Chromatography/High Accuracy/High Resolution Mass Spectrometry for Doping Control Analysis

Frontiers in Chemistry, 2020
Trenbolone is a synthetic anabolic-androgenic steroid, which has been misused for performance enhancement in sports. The detection of trenbolone doping in routine sports drug testing programs is complex as methods utilizing gas chromatography/mass ...
Marlen Putz, Thomas Piper, Mario Thevis
doaj   +1 more source

System to screen and purify active ingredients from herbal medicines using hydrogel‐modified human umbilical vein endothelial cell membrane chromatography coupled with semi‐preparative high‐performance liquid chromatography‐offline‐high‐performance liquid chromatography‐mass spectrometry [PDF]

, 2023
Hui Huang, Yabin Dai, Yuefen Zhang, Yongning Li, Huazhen Ye, Dan Guo, Qiaomei Lu, Xiaohua Cai   +7 more
openalex   +1 more source

Sex Hormones Associate With Amyotrophic Lateral Sclerosis Risk and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) risk differs by sex and age, implicating sex hormones as potential modifiers. This study examined plasma levels of biologically active sex hormones and their association with ALS odds and survival in cases (females n = 131, males n = 189) and controls (females n = 138, males n = 150) from the University of ...
Stephen A. Goutman, David G. Stouffer, Dae‐Gyu Jang, Jihyun Park, Benjamin J. Murdock, Richard J. Auchus   +5 more
wiley   +1 more source