Results 51 to 60 of about 368,842 (254)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A Numerical Investigation of Flow Characteristics in a Cryogenic Perforated Plate Flowmeter for Vertical Pipe Applications

Energies
To address the research gap regarding the flow characteristics of cryogenic perforated plate flowmeters in vertical pipes and to enhance measurement reliability in challenging environments, this study investigates the flow characteristics of liquid ...
Yihan Tian, Zhijian Zhang, Zhaozhao Gao, Chen Cui, Liubiao Chen, Junjie Wang   +5 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Evaluation of Liquid Hydrogen/Hydrogen Peroxide Propellant Combination for Advanced Launch Vehicle Upper Stage

Aerospace
Hydrogen peroxide (H2O2) is a dense, storable oxidizer, but its suitability for high-energy upper stages is limited. This study evaluates liquid hydrogen–hydrogen peroxide (LH2/H2O2) as an alternate propellant using KSLV-II as the reference vehicle ...
Min-Seon Jo, Jeong-Yeol Choi
doaj   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Thermo-Fluid Dynamics Modelling of Liquid Hydrogen Storage and Transfer Processes

Hydrogen
The use of liquid hydrogen (LH2) as an energy carrier is gaining traction across sectors such as aerospace, maritime, and large-scale energy storage due to its high gravimetric energy density and low environmental impact. However, the cryogenic nature of
Lucas M. Claussner, Giordano Emrys Scarponi, Federico Ustolin   +2 more
doaj   +1 more source

Underground Hydrogen Storage: Comparison of High-pressure Hydrogen, Liquid Hydrogen, and Ammonia [PDF]

대한환경공학회지
One of the alternatives for effective storage of irregularly produced renewable energy is hydrogen energy. In order to realize a hydrogen-based society, not only environmentally friendly production of hydrogen but also effective storage is very important.
Yumin Park, Sejin Choe, Dahui Han, Gaeul Heo, Sokhee P. Jung   +4 more
doaj   +1 more source