Results 51 to 60 of about 366,955 (255)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analysis of the Dynamic Characteristics of the Pump Valve System of an Ultra-High Pressure Liquid Hydrogen Reciprocating Pump

Energies, 2022
This paper developed a 3D physical model of the hydraulic end of a high-pressure liquid hydrogen reciprocating pump to research the dynamic characteristics of the pump valve system.
Nanbin Qiu, Xianwei Shang, Ruimin Liu, Ping Jin, Wanli Gao   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Research progress of annulus insulation technology for cryogenic liquid hydrogen pipelines

You-qi chuyun
[Objective] Liquid hydrogen has garnered significant interest for its high volumetric density and hydrogen purity. However, it easily evaporates during transportation due to its low boiling point, thus causing hydrogen loss.
NIU Shuaishuai, ZHAO Jie, LI Jingfa, WU Xiaohua, YU Bo, LI Jianli   +5 more
doaj   +1 more source

Preliminary Design and Simulation of a Thermal Management System with Integrated Secondary Power Generation Capability for a Mach 8 Aircraft Concept Exploiting Liquid Hydrogen

Aerospace, 2023
This paper introduces the concept of a thermal management system (TMS) with integrated on-board power generation capabilities for a Mach 8 hypersonic aircraft powered by liquid hydrogen (LH2).
Davide Ferretto, Nicole Viola
doaj   +1 more source

Hydrogen storage in liquid hydrogen carriers

Progress in Energy, 2023
Efficient storage of hydrogen is one of the biggest challenges towards a potential hydrogen economy. Hydrogen storage in liquid carriers is an attractive alternative to compression or liquefaction at low temperatures. Liquid carriers can be stored cost-effectively and transportation and distribution can be integrated into existing infrastructures.
Ulucan, Tolga Han, Akhade, Sneha A., Ambalakatte, Ajith, Autrey, Tom, Cairns, Alasdair, Chen, Ping, Cho, Young Whan, Gallucci, Fausto, Gao, Wenbo, Grinderslev, Jakob B., Grubel, Katarzyna, Jensen, Torben R., de Jongh, Petra E., Kothandaraman, Jotheeswari, Lamb, Krystina E., Lee, Young Su, Makhloufi, Camel, Ngene, Peter, Olivier, Pierre, Webb, Colin J., Wegman, Berenger, Wood, Brandon C., Weidenthaler, Claudia   +22 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Analysis of liquid hydrogen power systems for near space unmanned aerial vehicles

Hangkong gongcheng jinzhan
For near space unmanned aerial vehicles(NSUAVs), efficient power type is the key to support their long flights. It is considered that the "airborne liquid hydrogen storage + hydrogen fuel cell" scheme is in line with the trend of NSUAVs' greater ...
GAO Yanfeng, SONG Qi, XIE Gaofeng, WANG Xueke, WANG Mingfu   +4 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

A Numerical Investigation of Flow Characteristics in a Cryogenic Perforated Plate Flowmeter for Vertical Pipe Applications

Energies
To address the research gap regarding the flow characteristics of cryogenic perforated plate flowmeters in vertical pipes and to enhance measurement reliability in challenging environments, this study investigates the flow characteristics of liquid ...
Yihan Tian, Zhijian Zhang, Zhaozhao Gao, Chen Cui, Liubiao Chen, Junjie Wang   +5 more
doaj   +1 more source