Results 41 to 50 of about 660,003 (313)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Quality of giant freshwater prawn (Macrobrachium rosenbergii) during the storage at −18°C as affected by different methods of freezing

International Journal of Food Properties, 2018
This study investigated the effects of liquid nitrogen quick-freezing, −35°C air-blast freezing, and −18°C refrigerator direct-freezing on quality retention of frozen giant freshwater prawns using various indicators: microscopic structure ...
Lixia Yu, Qixing Jiang, Dawei Yu, Yanshun Xu, Pei Gao, Wenshui Xia   +5 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Investigation of the impact of heating and liquid nitrogen (LN) cooling on the mechanical and acoustic emission (AE) properties of coal

Energy Exploration & Exploitation
Liquid nitrogen has emerged as a promising fracturing medium for unconventional natural gas extraction, particularly in the context of coalbed methane extraction, generating significant interest in recent times.
Lin Sun, Caifang Wu, Teng Teng, Zhengzheng Cao, Fei Liu, Yuhe Cai, Yi Xue, Yanzhao Zhu   +7 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Analysis on Parameters in Nitrogen Injection and Unloading by Coiled Tubing in Gas Wells with Liquid Accumulation

Shiyou jixie, 2022
During the operation of nitrogen injection and unloading by coiled tubing in gas wells with liquid accumulation,in order to optimize the parameters such as nitrogen injection displacement,gas injection depth,size of coiled tubing and running speed,based ...
Liu Xuehang, Ma Weiguo, Zhang Xianyong, Tang Qingyuan   +3 more
doaj  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A Study on Blowing Nitrogen Alloying of Stainless Steel 316L with VOD Refining

Teshugang, 2011
The effect of nitrogen partial pressure (33 ~ 100 kPa), nitrogen blowing time (0 ~50 min), nitrogen rate (0. 3 L/min) and liquid temperature (1 773 ~ 1 833 K) in normal atmosphere condition on nitrogen content in steel 316L (% ： 0. 31C, 16.
时彦林, 包燕平, 董中奇
doaj  

Insulation characteristics of polyimide film used in liquid nitrogen of compact HTS transformers

IET Generation, Transmission & Distribution
Since compact high temperature superconducting (HTS) transformer has a small size and high efficiency, it can meet the requirements of high‐voltage transformers for vehicle‐mounted mobile substation.
Qibin Zhou, Yijie Xiao, Xiaoyan Bian, Feipeng Tang, Xi Wang   +4 more
doaj   +1 more source