Results 51 to 60 of about 1,453,212 (197)
Advanced Science, EarlyView.A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung +15 more
wiley +1 more source
Advanced Science, EarlyView.The WTP is a key component of static drainage PEMFCs, enabling cathode water removal and gas sealing through capillary forces. This work investigates the mechanisms governing WTP drainage and sealing performance and develops predictive approaches for WTP design optimization.
Mengdi Guo +3 more
wiley +1 more source
A Model-Based Method for Leakage Detection of Piston Pump Under Variable Load Condition
IEEE Access, 2019 Hydraulic systems have been widely used in construction machinery, aeronautics, astronautics, automobiles, shipping, and other fields. Piston pumps are power source and core component in the hydraulic system. The detection and assessment of leakage fault
Hongbin Tang, Wenxian Yang, Zichao Wang
doaj +1 more source
An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2
Advanced Science, EarlyView.Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu +7 more
wiley +1 more source
ThermoThe acceleration of climate change and increasing weather-related disasters require more active utilization of renewable energy. To maximize the use of renewable energy, energy storage is an essential part.
Barah Ahn, Macey Schmetzer, Paul I. Ro
doaj +1 more source
INFLUENCE OF THE PRESSURE AND TEMPERATURE ON VOLUME LOSSES BETWEEN PISTON AND CYLINDER AT OIL EXTRACTION PUMPS [PDF]
Romanian Journal of Petroleum & Gas Technology, 2020 The pressure and temperature influence oil density, viscosity, and modulus of elasticity. Their variation influences the flow through the piston-barrel interstitial to oil extraction pumps and the liquid flow that is lost through this gap. A model with
Ion Stoian-Albulescu +2 more
doaj
Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications
Advanced Science, EarlyView.Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen +11 more
wiley +1 more source
Zhileng xuebao, 2014 To study the platform piston wind distribution characteristics from the mechanism, it is put forward that the characteristics of platform piston wind conform to the attached jet theory, combining the theory modeling, field measurement and liquid scale ...
Wang Lihui +6 more
doaj
The effect of friction force and cavitation on wear in piston-cylinder assemblies
MATEC Web of Conferences, 2018 Both in engines and test rigs, cavitation in piston-ring lubrication is a subject studied by many researchers in the past. Although there is no sufficient evidence of cavitation erosion on the surface of the liner, this phenomenon is studied as part of ...
Dellis Polychronis
doaj +1 more source
Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management
Advanced Science, EarlyView.A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao +9 more
wiley +1 more source