Results 91 to 100 of about 10,251 (259)

Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Subsets of midbrain dopamine (DA) neurons express the vesicular glutamate transporter VGLUT2 and can release the excitatory neurotransmitter glutamate. VGLUT2+ DA neurons of the substantia nigra pars compacta (SNc) were shown to be more resistant to neurodegeneration in animal models of Parkinson's disease (PD ...
Sivakumar Srinivasan, Christian Pifl, Thomas Steinkellner   +2 more
wiley   +1 more source

The DEuterated SCintillator Array for Neutron Tagging

EPJ Web of Conferences, 2014
A neutron tagging array based upon liquid deuterated scintillators is being developed for the study of neutron-rich systems. The DEuterated SCintillator Array for Neutron Tagging, or DESCANT, will serve as an auxiliary detector for both the TIGRESS and ...
Wong J., Bildstein V., Garrett P.E., Bandyopadhyay D., Bangay J., Bianco L., Demand G., Deng G., Finlay A., Hadinia B., Leach K.G., Liblong A., Svensson C.E., Sumithrarachchi C., Ball G.C., Churchman R., Garnsworthy A., Hackman G., Pearson C.J., Martin J.P., Ashley S.F., Crider B.P., McEllistrem M.T., Peters E.E., Prados-Estevez F.M., Yates S.W., Vanhoy J.R.   +26 more
doaj   +1 more source

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

Facilitated Transport of Organic Contaminants in a High Concentration, Multicomponent Plume

Groundwater Monitoring &Remediation, EarlyView.
Abstract A field experiment evaluated the transport of organic contaminants in a plume from hazardous waste disposal areas at the Rocky Mountain Arsenal. The plume contained many xenobiotic contaminants, with widely varying expected mobilities.
D. M. Mackay, B. Myller, G. C. Bianchi‐Mosquera, B. D. Honeyman, M. Schirmer, R. M. Allen‐King, W. P. Ball, R. L. Stollar   +7 more
wiley   +1 more source

Penetration enhancement effects of topically applied crosslinked hyaluronic acid

International Journal of Cosmetic Science, EarlyView.
Cross‐linked hyaluronic acid (HA) was demonstrated to enhance the topical delivery of a variety of hydrophilic actives into the skin. This phenomenon was observed for both small molecules and macromolecules, the latter of which was analysed with MALDI mass spectrometry imaging (MALDI‐MSI).
Aaron Cohen, Raphael Legouffe, Krystal House, Paul Duhamel, Aurore Tomezyk, Mathieu Gaudin, Junhong Mao, David Bonnel   +7 more
wiley   +1 more source

Search for charged excited states of dark matter with KamLAND-Zen

Physics Letters B
Particle dark matter could belong to a multiplet that includes an electrically charged state. WIMP dark matter (χ0) accompanied by a negatively charged excited state (χ−) with a small mass difference (e.g.
S. Abe, M. Eizuka, S. Futagi, A. Gando, Y. Gando, S. Goto, T. Hachiya, K. Hata, K. Hosokawa, K. Ichimura, S. Ieki, H. Ikeda, K. Inoue, K. Ishidoshiro, Y. Kamei, N. Kawada, Y. Kishimoto, M. Koga, M. Kurasawa, T. Mitsui, H. Miyake, D. Morita, T. Nakahata, R. Nakajima, K. Nakamura, R. Nakamura, R. Nakamura, J. Nakane, H. Ozaki, T. Sakai, I. Shimizu, J. Shirai, K. Shiraishi, R. Shoji, A. Suzuki, A. Takeuchi, K. Tamae, H. Watanabe, K. Watanabe, S. Obara, S. Yoshida, S. Umehara, K. Fushimi, K. Kotera, Y. Urano, A. Ichikawa, B.E. Berger, B.K. Fujikawa, J.G. Learned, J. Maricic, S.N. Axani, Z. Fu, J. Smolsky, L.A. Winslow, Y. Efremenko, H.J. Karwowski, D.M. Markoff, W. Tornow, S. Dell'Oro, T. O'Donnell, J.A. Detwiler, S. Enomoto, M.P. Decowski, K.M. Weerman, C. Grant, A. Li, H. Song   +66 more
doaj   +1 more source

Oxygen consumption from air and water, ammonia and urea‐N excretion, and Na+ fluxes during progressive aquatic hypoxia in Amazonian armoured catfish Pterygoplichthys gibbiceps and Pterygoplichthys pardalis

Journal of Fish Biology, EarlyView.
Abstract The Amazonian loricariid fish Pterygoplichthys gibbiceps, from the Rio Negro, and Pterygoplichthys pardalis, from the Rio Solimões, are facultative air‐breathers that can use the stomach as an air‐breathing organ. Measurement of oxygen uptake under progressive aquatic hypoxia revealed a relatively high hypoxia resistance of both species.
Bernd Pelster, Chris M. Wood, Adalberto Luis Val   +2 more
wiley   +1 more source

HYPOPHYSIS VERSUS HYPOTHALAMUS AS TARGET ORGAN FOR THE INHIBITORY EFFECT OF OESTROGENIC HORMONES—RESULTS OF EXPERIMENTS USING AUTORADIOGRAPHY AND LIQUID SCINTILLATION COUNTING [PDF]

, 1962
Arne Attramadal
openalex   +1 more source

Joint effects of elevated copper and temperature in juvenile Tambaqui exposed in black and white waters of the Amazon

Journal of Fish Biology, EarlyView.
Abstract This study aimed to investigate how exposure to elevated water temperature and metal concentration jointly affect the physiology of Amazonian fish. Aboard a research vessel in the Amazon, we evaluated the effects of water temperature (river T°C at 31.5°C and a + 4°C increase to 35.5°C) and of 3‐h copper (Cu) exposure (up to 600 μg/L) in ...
Anne Crémazy, Carolyn Morris, Susana Braz‐Mota, Chris M. Wood, Rafael M. Duarte, Ora E. Johannsson, Adalberto L. Val   +6 more
wiley   +1 more source

Optimum lithium loading of a liquid scintillator for neutron and neutrino detection. [PDF]

Nucl Instrum Methods Phys Res A, 2020
Bergeron DE, Mumm HP, Tyra MA, Rosa J, Nour S, Langford TJ.   +5 more
europepmc   +1 more source