Results 111 to 120 of about 4,777 (233)

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

British Journal of Pharmacology, Volume 183, Issue 17, Page 5315-5335, September 2026.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah, Joshua Richard, Suvankar Ghosh, Jillian Jerwick, Joice T. Gavali, Raymond B. Penn, Alexander D. MacKerell Jr, Deepak A. Deshpande   +7 more
wiley   +1 more source

The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells

British Journal of Pharmacology, Volume 183, Issue 18, Page 5516-5540, September 2026.
Background and Purpose Colorectal cancer is one of the most prevalent cancers worldwide, and novel precision medicine approaches are rapidly improving patient outcomes. Phosphodiesterase 4B (PDE4B) is a member of an enzyme family (PDE4) that hydrolyses intracellular cAMP to control spatial and temporal signalling cues.
Alina Zorn, John Daniel Pediani, Madihah Hussain, Jiayue Ling, Elaine Brown, Igor Belka, Eduardo Torres, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie, Yuan Yan Sin   +11 more
wiley   +1 more source

Determination of the Range and Spread-Out Bragg Peak Width of Proton Beams Using a Large-Volume Liquid Scintillator. [PDF]

Int J Part Ther, 2017
Henry T, Robertson D, Therriault-Proulx F, Beddar S.   +3 more
europepmc   +1 more source

Changes in photosynthesis and grazing facilitate growth of a mixotrophic protist under ocean acidification and warming

New Phytologist, Volume 251, Issue 5, Page 2574-2587, September 2026.
Grazing rates of Ochromonas CCMP2951 expressed as carbon obtained per mean cell volume (a) and Caut/het‐photosynthetically fixed carbon divided by carbon obtained through grazing (b) in the four experimental treatments. Summary Mixotrophic protists capable of both photosynthesis and phagotrophy are key members of marine plankton communities.
Shai Slomka, Jolanda M. H. Verspagen, Rocio B. Rodriguez‐Perez, Jef Huisman, Susanne Wilken   +4 more
wiley   +1 more source

Application of a low‐cost Geiger–Müller monitoring system for clinical radiation environments

Journal of Applied Clinical Medical Physics, Volume 27, Issue 8, August 2026.
Abstract Background Low‐cost Geiger–Müller detectors may support clinical radiation monitoring, but their response varies with radiation type and measurement conditions. Purpose To evaluate an Arduino‐based Geiger–Müller monitoring system in representative clinical radiation environments and determine whether condition‐specific calibration reduces ...
Jungsam Choi, Chaihong Rim, Hakyoung Kim, Wonho Lee   +3 more
wiley   +1 more source

Positively Charged Polymer‐Brush MOFs for Large‐Area, Pressure‐Resistant Gas Separation Membranes

Advanced Materials, Volume 38, Issue 43, 3 August 2026.
A universal POPA strategy enables positively charged polymer‐brush MOFs with self‐adaptive interfacial interlocking to resist aggregation under fast processing. This design ensures seamless dispersion within large‐area selective layers, achieving 1 m‐wide roll‐to‐roll fabrication of pressure‐resistant MMCMs with tunable CO2 separation performance ...
Yi Yang, Ye Yuan, Yuxiu Sun, Fei Shi, Chenyang Song, Weifan Wang, Qinghua Li, Menglong Sheng, Zhihua Qiao, Jingwei Hou, Anthony K. Cheetham, Zhi Wang   +11 more
wiley   +1 more source

Lead‐Free Chiral Hybrid Metal Halides for Circularly Polarized Light‐Emitting Diodes

Advanced Optical Materials, Volume 14, Issue 30, 14 August 2026.
Lead‐free chiral hybrid metal halides provide a versatile platform for realizing chiroptical responses through chiral modulation of metal–halide frameworks with diverse dimensionalities, induces inversion‐symmetry breaking and enables dissymmetric excited‐state transitions toward efficient circularly polarized luminescence and electroluminescence. This
Kun Zhu, Li Wan
wiley   +1 more source

Mixing‐Driven Defects and Composition Evolution in Multi‐Material Metal Additive Manufacturing

Advanced Science, Volume 13, Issue 45, 13 August 2026.
Operando synchrotron X‐ray imaging coupled with high‐fidelity multiphysics modeling uncovers how inter‐material mixing reshapes keyhole dynamics and drives distinct pore‐formation pathways in multi‐material laser powder bed fusion (LPBF). Composition‐dependent instabilities trigger defects, whereas rescanning suppresses porosity and homogenizes Cu ...
Zhilang Zhang, Steve Gaudez, Mario Togni, Steven Van Petegem, Markus Bambach, Mamzi Afrasiabi   +5 more
wiley   +1 more source

Linking DSC/TGA to Cell Levels: Energetics, Evolved Gases, and Thermal Safety of NMC811‐Graphite Micro‐Cell

Advanced Energy Materials, Volume 16, Issue 30, 12 August 2026.
A bottom‐up, component‐resolved framework combining DSC/TGA, evolved gas analysis, and in situ XRD reveals how decomposition pathways control energy release in partial and micro‐cell configurations. Separator‐free assemblies are dominated by cathode‐O2${\rm O}_2$/anode‐Li reactions, while the separator restricts oxygen transport, reshapes the reaction ...
Ayrton M. Yanyachi, Lingmin Lin, Siddhartha Nanda, Wenlong Li, Yijin Liu, Steven Swinnea, Hadi Khani, Donal Finegan, Ofodike A. Ezekoye   +8 more
wiley   +1 more source

Pulse Shape Discrimination of n/γ in Liquid Scintillator at PMT Nonlinear Region Using Artificial Neural Network Technique. [PDF]

Sensors (Basel)
Yun E, Choi JY, Kim SY, Joo KK.
europepmc   +1 more source