Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5
Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková +3 more
wiley +1 more source
Test Beam Results From A Very Forward Liquid Scintillator Calorimeter For The Lhc
We report on beam tests performed on a liquid scintillator calorimeter prototype designed to cover the very forward region in an experiment at the LHC. The liquid scintillator technique has known advantages related to high speed, low noise and radiation ...
V. Barassi +10 more
core
Root volatile profiling reveals domestication‐associated variation in methyl salicylate (MeSA) accumulation in tomato. Summary Methyl salicylate (MeSA) plays diverse roles in the aerial parts of plants. By contrast, its biosynthesis and function in roots remain poorly understood.
Weijiao Wang +5 more
wiley +1 more source
Azidophosphonamido Rhodium(I) and Iridium(I) Complexes: Synthesis, Properties, and Linkage Isomerism
A family of azidophosphonamido ligands and their corresponding rhodium(I) and iridium(I) complexes were synthesized. The rich reaction chemistry of these species revealed unusual linkage isomerization processes and bonding motifs. M = Rh, Ir; Mes = 2,4,6‐Me3C6H2. ABSTRACT A series of azidophosphonamido rhodium(I) and iridium(I) complexes ([iPr2P(N3R)NR]
Emily L. Trew +3 more
wiley +1 more source
Pulse Shape Discrimination of n/γ in Liquid Scintillator at PMT Nonlinear Region Using Artificial Neural Network Technique. [PDF]
Yun E, Choi JY, Kim SY, Joo KK.
europepmc +1 more source
Fast range measurement of spot scanning proton beams using a volumetric liquid scintillator detector. [PDF]
Hui C, Robertson D, Alsanea F, Beddar S.
europepmc +1 more source
Development and Performance Assessment of Single- and Double-Layer TbAG:Ce and YAG:Ce Composite Scintillators on GAGG:Ce Substrates for Optimized α-γ Discrimination and Pulse-Shape Analysis. [PDF]
Bachiri A +10 more
europepmc +1 more source
Development of Optical-Guiding Scintillators with Ultrafine (~12 μm) Uniform Scintillator Cores for High-Resolution X-Ray Imaging. [PDF]
Kamada K +9 more
europepmc +1 more source
Radioluminescence microscopy of tumor organoids enabled by a reconfigurable high-resolution imaging setup. [PDF]
Demianova S +5 more
europepmc +1 more source
Performance Characterization of a Plastic Scintillator Sensor for Fast Neutron, Thermal Neutron, and Gamma Ray Discrimination. [PDF]
Liu Y +6 more
europepmc +1 more source

