Results 121 to 130 of about 25,638 (254)

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Liraglutide alleviates sepsis-associated encephalopathy via attenuating neuronal damage, glial cell activation and mitochondrial dysfunction in a mouse model of sepsis

European Journal of Medical Research
Objective To explore the relevant mechanisms and principles by which liraglutide alleviates sepsis-associated encephalopathy (SAE) through reducing neuronal injury, glial cell activation and mitochondrial dysfunction.
Xiaoming Li, Jun Wang, Rongji Zhang, Haoran He, Linjue Wang, Yuliang Wang, Hongyu Yi   +6 more
doaj   +1 more source

Is there an association between liraglutide use and female breast cancer in a real-world setting?

, 2018
Donnie Funch,1 Kathleen Mortimer,1 Ling Li,1 Heather Norman,1 Atheline Major-Pedersen,2 Anne Helene Olsen,3 Margit S Kaltoft,4 David D Dore1,5 1Optum Epidemiology, Boston, MA, USA; 2Global Safety, Novo Nordisk A/S, Copenhagen, Denmark; 3Epidemiology ...
Norman H, Major-Pedersen A, Olsen AH, Dore DD, Kaltoft MS, Mortimer K, Li L, Funch D   +7 more
core  

Effect of liraglutide on blood pressure: a meta-analysis of liraglutide randomized controlled trials

, 2019
Background Several clinical trials have studied the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on glycometabolism and cardiovascular risk factors since they were identified.
Xu Zhao, Kun Huang, Meijie Zheng, Junting Duan   +3 more
core   +1 more source

Effect of interdisciplinary obesity care on metabolic markers and body weight in people with type 2 diabetes in a rural setting: A randomised controlled trial

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Management of type 2 diabetes includes medications that can unintentionally increase obesity and insulin resistance. This unblinded, single‐centre, randomised controlled trial focused on rural Australian adults with type 2 diabetes (aged 18–75 and body mass index [BMI] >30 kg/m2), measuring the effectiveness of a tailored interdisciplinary ...
Giuliana O. Murfet, Iain K. Robertson, Sharon P. Luccisano, Michelle L. Kilpatrick   +3 more
wiley   +1 more source

Liraglutide and obesity: a review of the data so far

, 2015
Ellen E Ladenheim Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA Abstract: The prevalence of obesity worldwide has nearly doubled since 1980 with current estimates of 2.1 billion in ...
Ladenheim EE
core  

The real‐world relationship between naltrexone/bupropion treatment and weight loss in Canada: A retrospective chart review

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary This study examined the change in weight at 6 months of naltrexone/bupropion (NB), a combination pharmacological therapy for weight management, in real‐world practice in Canada. The study was conducted through an observational, retrospective, single‐arm chart review of adult patients who attended the Wharton Medical Clinic in Ontario, Canada ...
Sean Wharton, Elham Kamran, Lehana Thabane, Peter Yin, Rebecca Christensen   +4 more
wiley   +1 more source

Elevated IL‐4 and IL‐13 Expression in Hailey‐Hailey Disease: Evidence for Th2‐Mediated Pathogenesis and Targeted Treatment

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Hailey‐Hailey disease (HHD) is a rare autosomal dominant blistering disorder caused by mutations in the ATP2C1 gene, which impair keratinocyte adhesion through disrupted calcium signaling. While traditionally considered a structural defect, recent studies suggest that Th2‐mediated inflammation may exacerbate disease pathology ...
Simonetta I. Gaumond, Victoria Soto, Beatriz Abdo Abujamra, Franco Rongioletti, John A. McGrath, Ivan Jozic, Paolo Romanelli   +6 more
wiley   +1 more source

The efficacy of interventions to prevent type 2 diabetes among women with recent gestational diabetes mellitus—First update of a living systematic review and meta‐analysis

Diabetic Medicine, EarlyView.
Abstract Introduction The increased risk of developing type 2 diabetes mellitus (T2DM) in the decade following childbirth among women with gestational diabetes mellitus (GDM) warrants early intervention. A prespecified update of a systematic review and meta‐analyses published in 2024 was performed, examining the efficacy of interventions to prevent ...
Vivian Y. J. Lee, Joseph Alvin Santos, Ben Kostyrka, Mohammad R. Monjur, Rong Liu, Gian Luca Di Tanna, Asita De Silva, Lakshmi K. Josyula, Devarsetty Praveen, Alpesh Goyal, Yashdeep Gupta, Nikhil Tandon, Anushka Patel   +12 more
wiley   +1 more source