GLP‐1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms
Obesity Reviews, EarlyView.ABSTRACT GLP‐1 receptor agonist medications have the potential to promote marked weight loss, but maximal and sustained benefit may be compromised by poor compliance and cessation of use. Development of next‐generation medications that address current obstacles to effective use and development of effective adjunct treatments will benefit from better ...
Giorgia Rutigliani +8 more
wiley +1 more source
The Effect of Liraglutide on the Hypolipidemic, Anti-Inflammatory, and Antioxidant Properties of Atorvastatin Mediated via the Nrf2/HO-1 Signaling Pathway: In Vivo and In Silico Validation. [PDF]
PharmaceuticsKamar SA +11 more
europepmc +1 more source
Obesity Reviews, EarlyView.ABSTRACT Background Gut microbiota‐derived metabolites are emerging as potential mediators between obesity and cardiometabolic conditions. While weight loss interventions modify microbiota composition, their effects on systemic microbial metabolites remain unclear.
Fernando Q. Iorra +5 more
wiley +1 more source
Potential of Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists in Mitigating Metabolic Side Effects Associated With Clozapine or Olanzapine Therapy: A Literature Review. [PDF]
CureusMeftah A +10 more
europepmc +1 more source
Obesity Reviews, EarlyView.ABSTRACT Obesity is a leading risk factor for premature morbidity and mortality, and an increasing public health challenge. This review aimed to systematically identify and appraise national and international clinical guidelines for the management of obesity in adults.
Paul Doody +7 more
wiley +1 more source
Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity Reviews, EarlyView.Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source
Correction to "Aggregation-driven expression of liraglutide precursors using engineered mini-tags in Escherichia coli". [PDF]
Protein Scieuropepmc +1 more source
Improved Glucagon Sensitivity Following Weight Loss: A Systematic Review and Meta‐Analysis
Obesity Reviews, EarlyView.ABSTRACT Objective This systematic review and meta‐analysis investigated the effect of weight loss in people with obesity on two biomarkers of glucagon resistance: fasting plasma glucagon and alanine. Methods A comprehensive search was conducted in Medline and Embase. Random‐effects meta‐analyses and correlation analyses were performed.
Hye‐Rin Charlotte Kim +4 more
wiley +1 more source
Liraglutide Modifies Gut Microbiota Without Modulating Doxorubicin-Induced Toxicity in Rats. [PDF]
Antioxidants (Basel)Tonon CR +17 more
europepmc +1 more source
Weight‐Lowering Drugs and Natural Female Fertility—A Systematic Review and Meta‐Analysis
Clinical Obesity, Volume 16, Issue 4, August 2026.ABSTRACT Overweight and obesity are global health concerns linked to impaired female fertility. Weight‐lowering drugs are an alternative for achieving weight loss; however, their effect on natural female fertility is unclear. A systematic review and meta‐analysis were conducted to summarise the literature on the effects of weight‐lowering drugs on ...
Shaikha Jabor Alnaimi +4 more
wiley +1 more source