Results 41 to 50 of about 25,638 (254)

Liraglutide in Adults with Type 2 Diabetes: Global Perspective on Safety, Efficacy and Patient Preference

Clinical Medicine Insights: Endocrinology and Diabetes, 2011
Incretin-based therapies have been gaining much attention recently as a new class of therapeutics for type 2 diabetes worldwide. Among them, glucagon-like peptide-1 receptor agonist liraglutide has been rapidly increasing its global usage.
Daisuke Yabe, Yutaka Seino
doaj   +1 more source

Fibroblast growth factor-21 is required for weight loss induced by the glucagon-like peptide-1 receptor agonist liraglutide in male mice fed high carbohydrate diets

Molecular Metabolism, 2023
Objective: Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RA) and fibroblast growth factor-21 (FGF21) confer similar metabolic benefits. GLP-1RA induce FGF21, leading us to investigate mechanisms engaged by the GLP-1RA liraglutide to increase ...
Thao D.V. Le, Payam Fathi, Amanda B. Watters, Blair J. Ellis, Gai-Linn K. Besing, Nadejda Bozadjieva-Kramer, Misty B. Perez, Andrew I. Sullivan, Jesse P. Rose, Laurie L. Baggio, Jacqueline Koehler, Jennifer L. Brown, Michelle B. Bales, Kaitlyn G. Nwaba, Jonathan E. Campbell, Daniel J. Drucker, Matthew J. Potthoff, Randy J. Seeley, Julio E. Ayala   +18 more
doaj   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

A study on the therapeutic effect of liraglutide on chronic renal failure rats by down-regulating TGF-β1 and α-SMA

Linchuang shenzangbing zazhi, 2020
Objective To explore the therapeutic effect of liraglutide on chronic renal failure(CRF)rats by down-regulating transforming growth factor-β1(TGF-β1)and α-smooth muscle actin(α-SMA).Methods Wistar rats were divided into sham group,chronic renal failure ...
CHEN Li, TANG Wen-zhuang, ZHU Mei-juan, CHEN Juan   +3 more
doaj  

Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons – Implications for energy balance and glucose control

Molecular Metabolism, 2019
Objective: The long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist, liraglutide, stimulates insulin secretion and efficiently suppresses food intake to reduce body weight.
Zhenyan He, Yong Gao, Linh Lieu, Sadia Afrin, Jianhong Cao, Natalie J. Michael, Yanbin Dong, Jia Sun, Hongbo Guo, Kevin W. Williams   +9 more
doaj   +1 more source

Urinary Proteome Differences in Patients with Type 2 Diabetes Pre and Post Liraglutide Treatment

Current Issues in Molecular Biology, 2023
Diabetes mellitus is a chronic multisystem disease with a high global prevalence. The glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide is known to lower glucose levels and reduce weight.
Mohamed Rafiullah, Hicham Benabdelkamel, Afshan Masood, Aishah A. Ekhzaimy, Mohthash Musambil, Salini Scaria Joy, Assim A. Alfadda   +6 more
doaj   +1 more source

Trends in the utilization, expenditure and costs of noninsulin glucose‐lowering drugs in the Medicaid population: Steady increases in glucagon‐like peptide‐1 receptor agonist and sodium–glucose transporter‐2 inhibitor use, prices and expenditure

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse changes in the utilization, expenditure and average cost of noninsulin glucose‐lowering drugs (GLDs) between 2008 and 2023. Methods This was a retrospective observational study of 2008–2023 data from the National Medicaid State Drug Utilization database.
Rawan O. Almadfaa
wiley   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Metabolic and neuroprotective effects of dapagliflozin and liraglutide in diabetic mice [PDF]

, 2017
This study assessed the metabolic and neuroprotective actions of the sodium glucose co-transporter-2 inhibitor dapagliflozin in combination with the GLP-1 agonist liraglutide in dietary-induced diabetic mice.
Bjourson, Anthony, Gault, V.A., Pathak, Varun, Varun Pathak, Maurice O’Kane, Pathak, V., Moffett, R Charlotte, Peter R Flatt, Vadivel Parthsarathy, Flatt, Peter R., Gault, Victor A., Moffett, R.C., Millar, P., Victor A Gault, Paul Millar, Bjourson, A.J., Flatt, P.R., Parthsarathy, Vadivel, Millar, Paul, O'Kane, Maurice, Pathak, Nupur M, Flatt, Peter R, Nupur Pathak, Anthony J Bjourson, Moffett, Charlotte, Pathak, Nupur, Pathak, N., Parthsarathy, V., R Charlotte Moffett, O'Kane, M., Bjourson, Anthony J.   +30 more
core   +1 more source

Comparative efficacy of GLP‐1 RA, tirzepatide and SGLT‐2 inhibitors in metabolic liver disease: A network meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aim Metabolic liver disease, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis, is a major cause of chronic liver dysfunction worldwide, creating an urgent need for effective treatments. This systematic literature review (SLR) and network meta‐analysis (NMA) systematically reviews and compares the efficacy and safety ...
Andrej Belančić, Christina Antza, Anastasios Poutachidis, Smaro Palaska, Elvira Meni Maria Gkrinia, Andrea Katrin Faour, Yusuf Ziya Sener, Seher Sener, Rehena Sultana   +8 more
wiley   +1 more source