Results 61 to 70 of about 25,638 (254)

A glucagon-like peptide-1 analog, liraglutide, ameliorates endothelial dysfunction through miRNAs to inhibit apoptosis in rats [PDF]

PeerJ, 2019
Background and Aims Many studies have revealed that glucagon-like peptide-1 has vasoprotective effects. In this study, we investigated whether liraglutide suppressed endothelial dysfunction and explored the mechanism involved.
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li   +3 more
doaj   +2 more sources

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source

Association Between Exercise and Treatment with Liraglutide in Obese Rats by Cafeteria Diet [PDF]

Brazilian Archives of Biology and Technology, 2019
The objective of this study was to evaluate the effect of liraglutide, an analog of glucagon-like peptide-1 (GLP-1) in association with physical exercise, on the metabolic and biochemical parameters of rats induced to obesity with a cafeteria diet.
Daiane Didek, Maiara Mikuska Cordeiro, João Lucas de Paula Xavier, Paulo Roberto Ribeiro, Thiago Rentz, Gilson Cesar Nobre Franco, Carla Cristine Kanunfre, Henriette Rosa de Oliveira Emilio, Dionízia Xavier Scomparin   +8 more
doaj   +1 more source

The diabetes drug Liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease [PDF]

, 2011
Type 2 diabetes is a risk factor for Alzheimer's disease, most likely linked to an impairment of insulin signaling in the brain. The incretin hormone glucagon-like peptide-1 (GLP-1) facilitates insulin signaling, and novel long-lasting GLP-1 analogs ...
McClean, Paula L., Vadivel Parthsarathy, Faivre, E., Hölscher, C., Parthsarathy, Vadivel, Faivre, Emilie, Parthsarathy, V,, Holscher, Christian, McClean, P.L., Christian Hölscher, Emilie Faivre, Paula L. McClean   +11 more
core   +1 more source

Economic evaluations of antiobesity medications: A systematic literature review

British Journal of Clinical Pharmacology, EarlyView.
The global prevalence of obesity is rising rapidly. With several antiobesity medications approved and many more in development, understanding their economic value is increasingly important. This study reviews full economic evaluations of approved antiobesity medications to assess cost‐effectiveness and inform reimbursement and access decisions.
Martina Jurković, Almir Fajkić, Andrea Katrin Faour, Mirna Momčilović, Petra Turčić, Andrej Belančić   +5 more
wiley   +1 more source

Feasibility, Adherence and Efficacy of Liraglutide Treatment in a Sample of Individuals With Mood Disorders and Obesity

Frontiers in Psychiatry, 2019
Background: Liraglutide is a once-daily injectable medication approved for the treatment of obesity. Hereby we report the feasibility, adherence and efficacy of liraglutide treatment in a sample of individuals with mood disorders and obesity.Methods and ...
Alessandro Cuomo, Simone Bolognesi, Arianna Goracci, Cristina Ciuoli, Bruno Beccarini Crescenzi, Giuseppe Maina, Gianluca Rosso, Edvige Facchi, Carla Maccora, Nicola Giordano, Valeria Verdino, Andrea Fagiolini   +11 more
doaj   +1 more source

Comparative effectiveness of liraglutide in the treatment of type 2 diabetes [PDF]

, 2014
Mauro Rigato, Gian Paolo Fadini Department of Medicine, University Hospital of Padova, Padova, Italy Abstract: Type 2 diabetes is characterized by a progressive decline in beta cell function, with consequent worsening of glycemic control.
RIGATO, MAURO, FADINI, GIAN PAOLO, Rigato M, Fadini GP   +3 more
core   +1 more source

Model‐Informed Approaches for Pediatric Type 2 Diabetes Evidence Generation: Insights from a Model‐Based Longitudinal HbA1c Meta‐Analysis from EMA Marketing Authorization Applications

Clinical Pharmacology &Therapeutics, EarlyView.
Evidence generation for antihyperglycemic therapies in pediatric type 2 diabetes mellitus (T2DM) remains challenging, with most randomized trials failing to demonstrate statistically significant reductions in glycated hemoglobin (HbA1c), partly due to substantial between‐subject variability.
Pieter J. Colin, Efthymios Manolis, Jeroen V. Koomen   +2 more
wiley   +1 more source

Liraglutide attenuates gefitinib-induced cardiotoxicity and promotes cardioprotection through the regulation of MAPK/NF-κB signaling pathways

Saudi Pharmaceutical Journal, 2020
Gefitinib is an effective treatment for patients with locally advanced non-small cell lung cancer. However, it is associated with cardiotoxicity that can limit its clinical use.
Abdullah F. AlAsmari, Nemat Ali, Fawaz AlAsmari, Wael A. AlAnazi, Musaad A. AlShammari, Naif O. Al-Harbi, Ali Alhoshani, Homood M. As Sobeai, Mohammed AlSwayyed, Mohammed M. AlAnazi, Nader S. AlGhamdi   +10 more
doaj   +1 more source

The Needle‐Free Frontier: Redefining the Limits of Transdermal Insulin Delivery

Exploration, EarlyView.
Wei and colleagues reported a pH‐responsive, charge‐switchable polyzwitterionic polymer carrier that achieves non‐invasive transdermal insulin delivery without external energy input. The approach leverages adaptive compatibility with the cutaneous microenvironment to shuttle functional macromolecules across intact skin and achieve definitive systemic ...
Junge Chen, Yuxuan Liu, Bozhang Xia, Julien Milon Essola, Xing‐Jie Liang   +4 more
wiley   +1 more source