Results 31 to 40 of about 1,899 (259)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Rediscovering the canon in literary-historical dimensions

Opera slavica, 2017
The contribution considers the literary canon as an unstable category in the synchronic and diachronic context of the literary ontogenesis of Russian literature.
Soňa Pašteková
doaj  

The Lithuanian High School Literary Canon: Reconstructing the Developments of a Century

Interlitteraria
This paper reconstructs the developments of the Lithuanian high school literary canon from 1918 to 2018. Drawing on the theoretical framework of descriptive canon research, attributed to the theoretical field of cultural sociology, we investigate how ...
Viktorija Šeina, Aistė Kučinskienė
doaj   +1 more source

The National Literary Canon in the Field of Tension Between Aesthetic and Ideological Principles. The Estonian Case with Indications to the Comparative Perspectives

Interlitteraria, 2013
The article is an attempt to outline some problems regarding the literary and non-literary factors which are at work in the formation of the canon. The central example used in this analysis is the interactions between aesthetic and ideological principles
Marja Unt
doaj   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Etnografias imaginárias: literatura, teoria e cânone por Pozuelo Yvancos

Caligrama: Revista de Estudos Românicos, 2011
Palavras-chave: José María Pozuelo Yvancos; Teoría del canon y literatura española; crítica literária.Keywords: José María Pozuelo Yvancos; Teoría del canon y literatura española; literary criticism.
Sabrina Sedlmayer, Gabriel Schünemann, Janine Rocha, Josué Borges de Araújo Godinho, Luciano Danilo Silva, Vinícius Ribeiro Pimentel, Yara Augusto   +6 more
doaj   +1 more source

Four‐Point Bending Tests at High Temperatures on Commercial MgO‐C Refractory Bricks with and Without Recyclate Considering Different Carbon Contents

Advanced Engineering Materials, EarlyView.
Four‐point bending tests are conducted in an argon atmosphere on commercial MgO‐C brick grades with and without MgO‐C recyclate from room temperature up to 1300 °C. No detrimental effect of the MgO‐C recyclates on bending strength is found. Instead, a decisive influence of the total carbon content is observed, with lower total carbon contents ...
Alexander Schramm, Lukas Knöchel, Thomas Schemmel, Christos G. Aneziris, Anja Weidner, Horst Biermann   +5 more
wiley   +1 more source

Die spore van Raka: oor herskrywing en kanonisering (Deel 1)

Tydskrif vir Letterkunde, 2017
Every literary system possesses a canon with the classical canon as the most stable and simultaneously the one with the most restrictive access. Writers and texts can only maintain their position within the canon through continuous rewriting: critical ...
H. P. Van Coller, A. Van Jaarsveld
doaj  

Youth literature reading and storytelling

Knjižnica, 2011
Purpose: The aim of the study is to update the definition of Slovenian children’s literature from the perspective of literary criticism, audiences and reception.
Milena Mileva Blažić, Anja Štefan
doaj   +1 more source

Injectable Dual‐Network Hydrogel System for Osteochondral Repair Combining Immunomodulation, Mechanical Adaptability, and Enhanced Tissue Integration

Advanced Functional Materials, EarlyView.
A UV‐triggered injectable dual‐network hydrogel is reported as the first application of bletilla striata polysaccharide (BSP) in osteochondral repair. By integrating methacrylamide‐modified BSP and nitrobenzaldehyde‐functionalized hyaluronic acid, the system achieves immunomodulation, mechanical reinforcement, and dynamic tissue adhesion, thereby ...
Jiaming Cui, Feifei Zhou, Yuan Luo, Tao Ouyang, Huiwu Zhang, Songmiao Cheng, Qiang Li, Xu Jiang, Yingying Yu, Yicheng Wang, Hong Ming   +10 more
wiley   +1 more source