Results 31 to 40 of about 2,728 (287)
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Rolig, Peng, and colleagues have shed new light on how dual blockade of PD1 and LAG3 enhances antitumor immunity. They found that response to immunotherapy with anti‐PD1 + anti‐LAG3 was associated with reprogramming of canonically suppressive CD4+ regulatory T cells to an inflammatory state.
Tullia C. Bruno, Anthony R. Cillo
wiley +1 more source
NATIONAL LITERARY CANON UNDER TRANSLATION
Филологический класс, 2019 This study focuses on problems of literary translation and of national literary canon transformation in a target culture, and, as a result, the fate of the original text in the receiving culture.
doaj +1 more source
Investigating the Canon: The Reader as Detective in Reworkings of 'Madame Bovary' and 'Jane Eyre'
Modern Languages Open, 2023 Since the 1990s, a trend towards adapting, rewriting, or otherwise engaging with the literary canon—especially the nineteenth-century novel—via the popular genre of crime fiction may be observed in both French and English.
Katie Jones
doaj +1 more source
Molecular Oncology, EarlyView.Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley +1 more source
Etnografias imaginárias: literatura, teoria e cânone por Pozuelo Yvancos
Caligrama: Revista de Estudos Românicos, 2011 Palavras-chave: José María Pozuelo Yvancos; Teoría del canon y literatura española; crítica literária.Keywords: José María Pozuelo Yvancos; Teoría del canon y literatura española; literary criticism.
Sabrina Sedlmayer +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Youth literature reading and storytelling
Knjižnica, 2011 Purpose: The aim of the study is to update the definition of Slovenian children’s literature from the perspective of literary criticism, audiences and reception.
Milena Mileva Blažić, Anja Štefan
doaj +1 more source
Liver‐specific lncRNAs associated with liver cancers
FEBS Open Bio, EarlyView.Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina +3 more
wiley +1 more source