Results 51 to 60 of about 1,954 (264)
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
The Canon Pro and Contra: 'The Canon is Dead-Long Live Pick and Mix'
Miscelánea: A Journal of English and American Studies, 2004 The chief argument against the traditional canon is, of course, that it has been a vehicle for national superiority. Yet it is indubitably the case that the creation of a canon of English literature over the centuries is indeed closely bound up with the
Herbert Grabes
doaj +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Teksty Drugie, 2018 Ulicka tackles three related issues: the apparently peripheral status of Polish literary theory, its absence from the global canon, and the mechanisms behind this state of affairs.
Danuta Ulicka
doaj
THE VIEW FROM THE EAST ON THE PROBLEM FIELD OF WESTERN LITERARY AND THEORETICAL STU [PDF]
Вісник університету ім. А. Нобеля. Серія Філологічні наукиThe study aims to determine the status of modern theoretical literary debate within the context of scientific theorizing in China and Japan. Growing understanding of the crisis of Euro-Atlantic literary-theoretical thought in the first two decades of ...
Olena A. Mashchenko
doaj +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
Recherches, 2019 Literary text and literature, as a cultural expression of a community, take a necessary place in the teaching of a second language, understood from the communicative and social point of view.
Xaquín Núñez Sabarís
doaj +1 more source
Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani +10 more
wiley +1 more source
A READING OF THE FORMATION PROCESS OF THE LITERARY RULES:
Travessias, 2007 This article aims at to expose a partner-historical reading of the process of formation of the literary canon proposing, in the same way, your problematizao.
Mirele Carolina Werneque Jacomel
doaj
Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang +4 more
wiley +1 more source