Results 31 to 40 of about 1,954 (264)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

The Lithuanian High School Literary Canon: Reconstructing the Developments of a Century

open access: yesInterlitteraria
This paper reconstructs the developments of the Lithuanian high school literary canon from 1918 to 2018. Drawing on the theoretical framework of descriptive canon research, attributed to the theoretical field of cultural sociology, we investigate how ...
Viktorija Šeina, Aistė Kučinskienė
doaj   +1 more source

The National Literary Canon in the Field of Tension Between Aesthetic and Ideological Principles. The Estonian Case with Indications to the Comparative Perspectives

open access: yesInterlitteraria, 2013
The article is an attempt to outline some problems regarding the literary and non-literary factors which are at work in the formation of the canon. The central example used in this analysis is the interactions between aesthetic and ideological principles
Marja Unt
doaj   +1 more source

Small RNA pathways in mammalian oocytes

open access: yesFEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Die spore van Raka: oor herskrywing en kanonisering (Deel 1)

open access: yesTydskrif vir Letterkunde, 2017
Every literary system possesses a canon with the classical canon as the most stable and simultaneously the one with the most restrictive access. Writers and texts can only maintain their position within the canon through continuous rewriting: critical ...
H. P. Van Coller, A. Van Jaarsveld
doaj  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

Die spore van Raka: Oor herskrywing en kanonisering (Deel 2)

open access: yesTydskrif vir Letterkunde, 2017
Every literary system possesses a canon with the classical canon as the most stable and simultaneously the one with the most restrictive access. Writers and texts can only maintain their position within the canon through continuous rewriting: critical ...
H.P. Van Coller, A. Van Jaarsveld
doaj  

Youth literature reading and storytelling

open access: yesKnjižnica, 2011
Purpose: The aim of the study is to update the definition of Slovenian children’s literature from the perspective of literary criticism, audiences and reception.
Milena Mileva Blažić, Anja Štefan
doaj   +1 more source

NATIONAL LITERARY CANON UNDER TRANSLATION

open access: yesPhilological Class, 2019
This study focuses on problems of literary translation and of national literary canon transformation in a target culture, and, as a result, the fate of the original text in the receiving culture. The authors refer to a number of methods, namely, comparative literary studies methods, and contrastive analysis in national translation history and in cross ...
Olga Grigoryevna Sidorova   +1 more
openaire   +4 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

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