Results 71 to 80 of about 627,418 (357)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Creativity Studies, 2012 Within the field of meaning (re)production, the newly fashioned media theories have been stemming from Marshall McLuhan's and Mikhail Bakhtin‘s “hybrids” and generating what we are presently experiencing as flexible theoretical phenomena, exposed to ...
Aida Elisabeta Osian
doaj +1 more source
\u3cem\u3eFrankenstein\u3c/em\u3e, Feminism, and Literary Theory [PDF]
, 2003 Cave ab homine unius libri, as the Latin epigram warns us: beware the author of one book. Frankenstein has so overshadowed Mary Shelley\u27s other books in the popular imagination that many readers believe - erroneously - that she is a one-book author.
Hoeveler, Diane
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Augustin Buzura’s Orgolii: on the “faces” of Romanian communism [PDF]
Diversitate si Identitate Culturala in EuropaThis study aims to demonstrate that Romanian novelists of the 1960s unveil both the terror of the Dej regime and the more sophisticated methods of torture employed under Ceaușescu.
Ana-Maria BĂNICĂ
doaj
BOOK REVIEW OF ONE NIGHT WITH PRINCE CHARMING WRITTEN BY ANNA DEPALO [PDF]
, 2015 According to Wellek and Warren (1976: 94) in Theory of Literature, literature represents life and life is, in large measure, a social reality, even though the natural word and the inner or subjective world of the individual have also been objects of ...
Rostanti, Diana
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
OD REDAKCJI: Queerowe konteksty literatury polskiej
Zagadnienia Rodzajów LiterackichThe text concerns the application of concepts and terms created within queer studies to a Polish context, especially in literary studies. The issue discussed by participants in the debate on the possibility of assimilating queer studies into the Polish ...
Agnieszka Izdebska
doaj +1 more source
A Poética Sociológica de Medviédev e Sua Atualidade
MatLit, 2013 Review of Pável Nikoláievitch Medviédev. O método formal nos estudos literários: introdução crítica a uma poética sociológica, Trad. Ekaterina Vólkova Américo e Sheila Camargo Grillo, São Paulo, Contexto, 2012, 269 pp. [1ª ed., Leningrado, Pribói, 1928].
Matheus de Brito
doaj +1 more source