Results 111 to 120 of about 134,123 (268)

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

open access: yesAdvanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao   +36 more
wiley   +1 more source

Unpaired Learning‐Enabled Nanotube Identification from AFM Images

open access: yesAdvanced Science, EarlyView.
Identifying nanotubes on rough substrates is notoriously challenging for conventional image analysis. This work presents an unpaired deep learning approach that automatically extracts nanotube networks from atomic force microscopy images, even on complex polymeric surfaces used in roll‐to‐roll printing.
Soyoung Na   +10 more
wiley   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu   +6 more
wiley   +1 more source

Translation of Personal Names in Klingon “Hamlet”

open access: yesRiCognizioni
The translation of literary classics into constructed languages (ConLangs), particularly artificial languages (ArtLangs) like Klingon, offers unique insights into the interplay between language, culture, and translation theory. This paper focuses on the
Chiara Meluzzi
doaj   +2 more sources

Sonja-Anja-Alisa, ovvero, Le avventure di "Alice" in Russia [PDF]

open access: yes
Lewis Carroll’s Alice’s Adventures in Wonderland (1865) is a text rich of cultural and literary references to Victorian England. This feature is one of the major obstacles to translating this work since the transfer of cultural markers from source to ...
Sicari,
core  

3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction

open access: yesAdvanced Science, EarlyView.
A human‐derived 3D bioprinted fat–myocardium model is developed to investigate how adipocyte hypertrophy drives atrial dysfunction in obesity. Palmitate‐induced adipocyte hypertrophy promotes adipose dysfunction that impairs atrial cardiomyocyte metabolism and electrophysiology through both paracrine and direct interactions. This platform recapitulates
Lara Ece Celebi, Pinar Zorlutuna
wiley   +1 more source

Can We Say an Ear of Cabbage : On Translating Wordplay in Xi Xi’s Poetry

open access: yes, 2017
This article reflects on the translation of wordplay in the poetry of Hong Kong author Xi Xi. Xi Xi is a highly imaginative poet: much of her poetry hinges upon specificities of the Chinese language, and one might well ask if this makes her work ...
FEELEY, Jennifer
core  

Transparent Transfer‐Free Ultrasmall Multilayer Graphene Microelectrodes Enable High Quality Recordings in Brain Slices

open access: yesAdvanced Science, EarlyView.
A transfer‐free fabrication method enables multilayer graphene microelectrodes as small as 10 µm, eliminating reliability issues of manual graphene transfer. These electrodes record neural activity in brain slices with exceptional signal‐to‐noise ratios (up to 25–40 dB) while maintaining optical transparency for multimodal applications.
Nerea de Alvarez de Eulate   +7 more
wiley   +1 more source

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