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In 2007 there were a total of 2, 293, 257 prisoners in the United States (US Department of Justice). The number of individuals incarcerated in the U.S. has been increasing over the last 30 years (Jones & Pratt 2008).
Massey, Jaclyn
core +1 more source
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao+7 more
wiley +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Introduction: Chronic drug use has been associated with a wide range of neuropsychological deficits. Therefore, this study aimed to evaluate the performance of the neuropsychological functions among three groups of opioids abusers, treated with methadone
MA Sepahvandi+3 more
doaj
A Pragmatic Approach to Rhetorical Technique of "Exaggeration" Based on Grice’s "Cooperative Principle" [PDF]
Exaggeration is among the most prominent rhetorical techniques that has long been of significant interest to linguists and scholars, specifically under the discipline of Badi (rhetorical embellishment).
Hassan Rahmani+4 more
doaj +1 more source
Case report and literature review
Introduction: We report the case of a multicentric Castleman disease (MCD) with initial renal involvement. Although the renal involvement in this case was typical of MCD, it constitutes a rare presentation of the disease, and in our case the renal ...
Adrien Flahault+8 more
semanticscholar +1 more source
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää+2 more
wiley +1 more source
Stress and Heart Rate Variability: A Meta-Analysis and Review of the Literature
Objective Physical or mental imbalance caused by harmful stimuli can induce stress to maintain homeostasis. During chronic stress, the sympathetic nervous system is hyperactivated, causing physical, psychological, and behavioral abnormalities. At present,
Hye-Geum Kim+4 more
semanticscholar +1 more source
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu+17 more
wiley +1 more source