Results 71 to 80 of about 5,208,749 (290)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

The Subject Specialist in Higher Education - A Review of the Literature [PDF]

open access: yes, 2006
Review of the changing role of the subject librarian over the ...
Feetham, Margaret
core  

Towards Inclusive Teacher Education: Sensitising individuals to how they learn [PDF]

open access: yes, 2006
Higher Education has struggled to acknowledge and translate into better teaching and learning practices that sizeable literature base suggesting a link between cognitive style, learning preferences and performance.
Evans, Carol, Waring, Michael
core   +2 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

open access: yes
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana   +8 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Entrepreneurial leadership: what is it and how should it be taught? [PDF]

open access: yes, 2011
Main ArticleWe offer a comprehensive review of the literature relating to entrepreneurial leadership, noting that there are diverse understandings of the concept and little exploration of how best to teach it. We next present empirical data from a survey
Harrison, Pegram, Roomi, Muhammad Azam
core  

Evidence-Based Interventions that Promote Resident Wellness from the Council of Emergency Residency Directors [PDF]

open access: yes, 2020
Initiatives for addressing resident wellness are a recent requirement of the Accreditation Council for Graduate Medical Education in response to high rates of resident burnout nationally.
Bailitz, John   +6 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Exploring Collaborative Approaches in Literature Education: Fostering Creative Expression and Student Engagement through Adaptation of “An Inspector Calls”

open access: yesJournal of Languages and Language Teaching
Encouraging undergraduate students to engage in literary interpretation fosters creative thinking and enables them to perceive contexts in diverse and meaningful ways. Collaborative efforts among students to develop a unified interpretation of a new plot
Evelyn Jayapalan   +5 more
doaj   +1 more source

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