Results 81 to 90 of about 18,931,914 (272)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
مجله علوم روانشناختی, 2020 Background: Numerous studies have examined the effectiveness of compassionate education on the conscious mind and the study of pleasure-seeking, historical memory, and sleep quality in depressed individuals.
Adeleh Yousefi Siakoucheh +2 more
doaj
Antarctic Record, 1972 An attempt was made at the measurements of surface velocities of ice flow in several places along the east coast of Lutzow-Holm Bay in 1960 and 1961. Difficulties in preserving stakes and in selecting suitable sites for surveying and the limited time ...
Kenzo FUJIWARA, Yoshio YOSHIDA
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
General Dynamics Corporation Report GA-471
, 1958 From foreword: The TRIGA is a novel and unusually safe training, research, and isotope-production reactor that contains solid homogeneous uranium-zirconium-hydride-moderator fuel elements and operates at power levels in the range of from 10 kw to 250 ...
General Dynamics Corporation. General Atomic Division
core
Antoine Sénanque: When the pen reveals the secrets of the stethoscope
Dialogues in HealthPurpose: This article investigates the narrative work of neurologist and novelist Antoine Sénanque by situating it at the intersection of medical practice, literary fiction, and social justice.
El Gaoual Ilham +2 more
doaj +1 more source
The relationship between existential concerns, incompleteness, and insight with dimensions of obsessive-compulsive disorder in female students [PDF]
Journal of Research in PsychopathologyThis study aimed to investigate the relationship between existential concerns, incompleteness, and insight with dimensions of obsessive-compulsive disorder in female students.
Mobina Rezaei +2 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source