Results 81 to 90 of about 8,730,279 (287)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The relationship between existential concerns, incompleteness, and insight with dimensions of obsessive-compulsive disorder in female students [PDF]
Journal of Research in PsychopathologyThis study aimed to investigate the relationship between existential concerns, incompleteness, and insight with dimensions of obsessive-compulsive disorder in female students.
Mobina Rezaei +2 more
doaj +1 more source
Gravitational waves in modified teleparallel theories of gravity
, 2018 Teleparallel theory of gravity and its modifications have been studied extensively in literature. However, gravitational waves has not been studied enough in the framework of teleparallelism.
Abedi, Habib, Capozziello, Salvatore
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
مجله علوم روانشناختی, 2020 Background: Numerous studies have examined the effectiveness of compassionate education on the conscious mind and the study of pleasure-seeking, historical memory, and sleep quality in depressed individuals.
Adeleh Yousefi Siakoucheh +2 more
doaj
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Antoine Sénanque: When the pen reveals the secrets of the stethoscope
Dialogues in HealthPurpose: This article investigates the narrative work of neurologist and novelist Antoine Sénanque by situating it at the intersection of medical practice, literary fiction, and social justice.
El Gaoual Ilham +2 more
doaj +1 more source
Antarctic Record, 1972 An attempt was made at the measurements of surface velocities of ice flow in several places along the east coast of Lutzow-Holm Bay in 1960 and 1961. Difficulties in preserving stakes and in selecting suitable sites for surveying and the limited time ...
Kenzo FUJIWARA, Yoshio YOSHIDA
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source