Results 31 to 40 of about 7,743 (185)

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, Volume 13, Issue 29, 22 May 2026.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Differences in macrophage pyroptosis and polarization induced by nano-/micro-calcium oxalate crystals

Journal of Nanobiotechnology
Objective This study aimed to compare the differences in pyroptosis and polarization of macrophages induced by different sizes of calcium oxalate monohydrate (COM) crystals and discuss the mechanism of kidney stone formation.
Xin-Yi Tong, Wei-Jian Nong, Run-Min Tan, Jian-Ming Ouyang   +3 more
doaj   +1 more source

Comparison of Endoplasmic Reticulum Stress and Pyroptosis Induced by Pathogenic Calcium Oxalate Monohydrate and Physiologic Calcium Oxalate Dihydrate Crystals in HK-2 Cells: Insights into Kidney Stone Formation

Cells
Endoplasmic reticulum stress (ERS) can activate pyroptosis through CHOP and TXNIP; however, the correlation between this process and the formation of kidney stones has not been reported.
Wei-Jian Nong, Xin-Yi Tong, Jian-Ming Ouyang   +2 more
doaj   +1 more source

Association between testicular microlithiasis, testicular cancer, cryptorchidism and history of ascending testis

International Brazilian Journal of Urology, 2006
OBJECTIVE: To prospectively determine the prevalence of testicular microlithiasis in symptomatic patients who were referred for scrotal ultrasound examination and to evaluate the possible association of testicular microlithiasis with testicular cancer ...
Stamatiou Konstantinos, Alevizos Alevizos, Mariolis Anargiros, Mihas Constantinos, Halazonitis Athanase, Bovis Konstantinos, Eleftherios Michail, Sofras Fragiskos   +7 more
doaj   +1 more source

Micro-Ureteroscopy as a Treatment of Renal Pelvis Lithiasis in Young Children

Frontiers in Pediatrics, 2021
Aim: Miniaturization of endoscopic instruments has allowed to improve the efficacy of kidney stone treatment in young children. Aim of the study is to evaluate the usefulness of microureteroscopy with 4.85F sheath in the treatment of renal stones in ...
Alberto Parente, Ruben Ortiz, Beatriz Fernández-Bautista, Laura Burgos, José Maria Angulo   +4 more
doaj   +1 more source

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Is there an association between urolithiasis and roux-en-y gastric bypass surgery?

International Brazilian Journal of Urology, 2009
Purpose: Several studies have documented high incidence of urinary lithiasis after jejunoileal by-pass. Roux-en-y gastric bypass surgery (RYGB) is currently the most common bariatric procedure.
Andre Costa-Matos, Luiz R. Guidoni, Kepler A. Carvalho, Roni C. Fernandes, Marjo D. Perez   +4 more
doaj   +1 more source

Isolated Kidney Transplant in Primary Hyperoxaluria‐1 Enabled by Small Interfering RNA (siRNA) Therapy. Is It Time for Change? Case Report and Review of the Literature

Pediatric Transplantation, Volume 30, Issue 5, May 2026.
ABSTRACT Background Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder characterized by excessive oxalate production that leads to nephrocalcinosis or nephrolithiasis and progressive kidney failure, associated with systemic oxalosis that is not reversed by dialysis. Pharmacological treatment is limited.
Shameer M. Habeeb, Eva Simkova, Samhar Al‐Akash, Hazem S. Awad, Haneen Yamin, Loai A. Eid, Watfa S. Aldhaheri, Waldo Concepcion, Martin Bitzan   +8 more
wiley   +1 more source

Endourological Management of Forgotten Encrusted Ureteral Stents

International Brazilian Journal of Urology, 2010
PURPOSE: To present our experience and discuss the various endourological approaches for treating forgotten encrusted ureteral stents associated with stone formation. MATERIALS AND METHODS: From July 2006 to December 2008, 14 patients (11 men and 3 women)
Kusuma V. R. Murthy, S. Jayaram Reddy, D. V. Prasad   +2 more
doaj   +1 more source

Meckel's Diverticulum Causing Sigmoid Knotting and Closed‐Loop Obstruction: A Rare Case Report From a Resource‐Limited Setting

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Meckel's diverticulum rarely causes large bowel obstruction through a fibrous band, leading to sigmoid knotting and closed‐loop gangrene. In patients presenting with acute intestinal obstruction without prior abdominal surgery, this etiology should be considered.
Biruk Umer Mohammed, Henok Bahru Wodajeneh, Ashenafi Tesfaye Bedada, Dereje Nigatu Elala, Bikila Gedefa Bekana, Bemnet Zegeye Ashenafi, Meskerem Abera Furno   +6 more
wiley   +1 more source