Results 21 to 30 of about 21,061 (257)

Parkinson’s Disease: Potential Actions of Lithium by Targeting the WNT/β-Catenin Pathway, Oxidative Stress, Inflammation and Glutamatergic Pathway

Cells, 2021
Parkinson’s disease (PD) is one of the major neurodegenerative diseases (ND) which presents a progressive neurodegeneration characterized by loss of dopamine in the substantia nigra pars compacta.
Alexandre Vallée, Jean-Noël Vallée, Yves Lecarpentier   +2 more
doaj   +1 more source

Identification and characterization of preventable adverse drug events in family medicine clinics from central Saudi Arabia

Saudi Journal of Medicine and Medical Sciences, 2023
Background: Medication errors can result in adverse drug events (ADEs) and cause considerable patient harm. Limited data are available from Saudi Arabia and the Middle East regarding the prevalence of preventable adverse drug events (pADEs) in primary ...
Ghadah A Assiri, Abdulelah S Bin Shihah, Mohammed K Alkhalifah, Ali S Alshehri, Abdullah H Alkhenizan   +4 more
doaj   +1 more source

Lithium: a potential therapeutic strategy in obsessive–compulsive disorder by targeting the canonical WNT/β pathway

Translational Psychiatry, 2021
Obsessive–compulsive disorder (OCD) is a neuropsychiatric disorder characterized b–y recurrent and distinctive obsessions and/or compulsions. The etiologies remain unclear.
Alexandre Vallée, Jean-Noël Vallée, Yves Lecarpentier   +2 more
doaj   +1 more source

Population Pharmacokinetics and Dosing Regimen of Lithium in Chinese Patients With Bipolar Disorder

Frontiers in Pharmacology, 2022
Background: Lithium is an effective medication approved for the treatment of bipolar disorder (BD). It has a narrow therapeutic index (TI) and requires therapeutic drug monitoring.
Zi-bin Jin, Zhuo Wu, Yi-fan Cui, Yi-fan Cui, Xue-peng Liu, Hong-bo Liang, Jia-yong You, Chen-yu Wang   +7 more
doaj   +1 more source

Facial processing in bipolar disorder is mediated by clinical and biological aspects

Brazilian Journal of Psychiatry, 2022
Objective: The process of detecting faces can be considered one of the initial steps in face recognition, which is essential for human interaction. We sought to investigate whether a face perception task reliably detects subtle perceptual disturbances ...
Irina I. Shoshina, Milena E. Oliveira, Gabriella M. Silva, Nathalia S. Negreiros, Fatima M. Felisberti, Thiago P. Fernandes, Natanael A. Santos   +6 more
doaj   +1 more source

Transcription-Driven Repurposing of Cardiotonic Steroids for Lithium Treatment of Severe Depression

Cells
Lithium is prescribed as a mood stabilizer for bipolar disorder and severe depression. However, the mechanism of action of lithium is unknown and there are major side effects associated with prolonged medication.
Richard Killick, Claudie Hooper, Cathy Fernandes, Christina Elliott, Dag Aarsland, Svein R. Kjosavik, Ragnhild Østerhus, Gareth Williams   +7 more
doaj   +1 more source

Challenging the Safety Threshold: Neurotoxicity in Bipolar Disorder Treatment with Lithium at Therapeutic Serum Levels

Psychiatry and Clinical Psychopharmacology
Bipolar disorder is a complex mental disorder that often requires long-term medication management. Lithium carbonate is widely used to prevent and treat the recurrence of bipolar disorder.
Jinbo Chen, Jun Zhu, Hehua Bao, Lijuan Tang, Benhan Li, Zixuan Chen, Yanli Zhang, Qiang Hu   +7 more
doaj   +1 more source

High lithium concentration at delivery is a potential risk factor for adverse outcomes in breastfed infants: a retrospective cohort study

International Journal of Bipolar Disorders, 2023
Background Neonatal effects of late intrauterine and early postpartum exposure to lithium through mother’s own milk are scarcely studied. It is unclear whether described symptoms in breastfed neonates are caused by placental lithium transfer or postnatal
Essi Whaites Heinonen, Katarina Tötterman, Karin Bäck, Ihsan Sarman, Lisa Forsberg, Jenny Svedenkrans   +5 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source