Results 51 to 60 of about 1,231,050 (361)

Can We Really Prevent Suicide? [PDF]

, 2012
Every year, suicide is among the top 20 leading causes of death globally for all ages. Unfortunately, suicide is difficult to prevent, in large part because the prevalence of risk factors is high among the general population. In this review, clinical and
A Fagiolini, A Roy, A Roy, AC Leon, AD Lopez, AF Jorm, AL Beautrais, AN Sabo, AP Chioqueta, B Schneider, B Schneider, B Spivac, B Stanely, B Stanley, B Yerevanian, BA Palmer, BN Gaynes, C Bushe, C Haw, CM Feltz-Cornelis van der, CW Tsai, D Fergusson, D Gunnell, D Shaffer, D Wasserman, DA Brent, DA Brent, DA Brent, EC Harris, F Cassidy, F Guzzetta, F Keller, FK Goodwin, FS Bridges, G Dieserud, G Isacsson, G Isacsson, G Sonneck, Gil Zalsman, GK Brown, GL Carter, GL Sidley, H Dumesnil, H Galfalvy, H Valtonen, HG Morgan, HJ Moller, HJ Moller, HJ Moller, HY Meltzer, J Fawcet, J Johnson, J Lonnqvist, JA Egeland, JB Luoma, JD Maser, JJ Lin, JJ Mann, JJ Mann, JM Boden, JMG Williams, K Hawton, K Hor, K Posner, K Szanto, KL Knox, KM Malone, L Tondo, LM Hayes, Lucas Giner, M Bauer, M Bauer, M Leitner, M Miller, M Olfson, M Panagioti, M Pompili, M Sarchiapone, M Shelef, MA Oquendo, MA Oquendo, MA Oquendo, MA Oquendo, Maria A. Oquendo, Maya Schwartz-Lifshitz, MD Rudd, MM Linehan, MP Pignone, N Tarrier, ND Kapusta, NM Melhem, O Bennewith, PA Wyman, PG Placidi, PH Soloff, PH Soloff, RD Gibbons, RJ Baldessarini, S Kelly, SH Kennedy, SP Pirkola, U Hegerl, U Hegerl, U Hegerl, UA Andersen, W Coryell, WA Watson, WD Hall, Z Rihmer, Z Rihmer, Z Rihmer, Z Rihmer   +111 more
core   +1 more source

Teratogenic risk and contraceptive counselling in psychiatric practice: analysis of anticonvulsant therapy [PDF]

, 2013
<p>Background: Anticonvulsants have been used to manage psychiatric conditions for over 50 years. It is recognised that some, particularly valproate, carbamazepine and lamotrigine, are human teratogens, while others including topiramate require ...
A Basan, A Wieck, Andrea Perry, D Taylor, E Perrucs, EB Samrén, FJE Vajda, H Grunze, JL Heffner, Julie Langan, L Citrome, L James, Maria Oto, N Adab, O Diav-Citrin, PA Lambert, S Fried, S Leucht, S Matalon, Scotland's Population, T Okuma, T Tomson, VK Hiilesmaa, World Health Organisation   +23 more
core   +2 more sources

Transcription-Driven Repurposing of Cardiotonic Steroids for Lithium Treatment of Severe Depression

Cells
Lithium is prescribed as a mood stabilizer for bipolar disorder and severe depression. However, the mechanism of action of lithium is unknown and there are major side effects associated with prolonged medication.
Richard Killick, Claudie Hooper, Cathy Fernandes, Christina Elliott, Dag Aarsland, Svein R. Kjosavik, Ragnhild Østerhus, Gareth Williams   +7 more
doaj   +1 more source

Facial processing in bipolar disorder is mediated by clinical and biological aspects

Brazilian Journal of Psychiatry, 2022
Objective: The process of detecting faces can be considered one of the initial steps in face recognition, which is essential for human interaction. We sought to investigate whether a face perception task reliably detects subtle perceptual disturbances ...
Irina I. Shoshina, Milena E. Oliveira, Gabriella M. Silva, Nathalia S. Negreiros, Fatima M. Felisberti, Thiago P. Fernandes, Natanael A. Santos   +6 more
doaj   +1 more source

Plasma Lithium Levels in the General Population: A Cross-Sectional Analysis of Metabolic and Dietary Correlates

Nutrients, 2020
Initial evidence suggests that lithium might affect life expectancy and the risk for different disease conditions, but most studies were conducted in patients on lithium medication. Little is known about the association of blood lithium levels within the
J. Enderle, Urte Klink, R. di Giuseppe, M. Koch, U. Seidel, K. Weber, M. Birringer, I. Ratjen, G. Rimbach, W. Lieb   +9 more
semanticscholar   +1 more source

Challenging the Safety Threshold: Neurotoxicity in Bipolar Disorder Treatment with Lithium at Therapeutic Serum Levels

Psychiatry and Clinical Psychopharmacology
Bipolar disorder is a complex mental disorder that often requires long-term medication management. Lithium carbonate is widely used to prevent and treat the recurrence of bipolar disorder.
Jinbo Chen, Jun Zhu, Hehua Bao, Lijuan Tang, Benhan Li, Zixuan Chen, Yanli Zhang, Qiang Hu   +7 more
doaj   +1 more source

Lamotrigine in the treatment of schizoaffective disorder [PDF]

, 1998
There is accumulating evidence for the efficacy of lamotrigine in the treatment of bipolar disorder, including bipolar depression, both as monotherapy and in combination with sodium valproate.
Erfurth, Andreas, Grunze, Heinz, Walden, Jörg   +2 more
core   +1 more source

Medication nonadherence in bipolar disorder: a narrative review

Therapeutic Advances in Psychopharmacology, 2018
A number of effective maintenance medication options exist for bipolar disorder (BD) and these are regarded as the foundation of long-term treatment in BD. However, nonadherence to medication is common in BD.
Ibrahim Jawad, S. Watson, Peter M Haddad, Peter S. Talbot, R. H. McAllister-Williams   +4 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

High lithium concentration at delivery is a potential risk factor for adverse outcomes in breastfed infants: a retrospective cohort study

International Journal of Bipolar Disorders, 2023
Background Neonatal effects of late intrauterine and early postpartum exposure to lithium through mother’s own milk are scarcely studied. It is unclear whether described symptoms in breastfed neonates are caused by placental lithium transfer or postnatal
Essi Whaites Heinonen, Katarina Tötterman, Karin Bäck, Ihsan Sarman, Lisa Forsberg, Jenny Svedenkrans   +5 more
doaj   +1 more source