Results 31 to 40 of about 124,423 (252)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstruction of Paleofire Emissions Over the Past Millennium From Measurements of Ice Core Acetylene

Geophysical Research Letters, 2020
Acetylene is a short‐lived trace gas produced during combustion of fossil fuels, biomass, and biofuels. Biomass burning is likely the only major source of acetylene in the preindustrial atmosphere, making ice core acetylene a powerful tool for ...
Melinda R. Nicewonger, Murat Aydin, Michael J. Prather, Eric S. Saltzman   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dynamic LIA advances hastened the demise of small valley glaciers in central Svalbard

Arctic Science
Most small land-terminating glaciers in Svalbard have experienced large recession since the Little Ice Age (LIA) and today are thin, cold, and largely inactive. This likely contrasts to their LIA conditions, but the observational record from that time is
Erik S. Mannerfelt, Andrew J. Hodson, Lena Håkansson, Harold Lovell   +3 more
doaj   +1 more source

Volcanism and the Little Ice Age [PDF]

PAGES news, 2008
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T. J. Crowley, G. Zielinski, B. Vinther, UDISTI, ROBERTO, K. Kreutz, J. Cole Dai, CASTELLANO, EMILIANO   +6 more
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Little Ice Age glacial geomorphology and sedimentology of Portage Glacier, South-Central Alaska [PDF]

Finisterra - Revista Portuguesa de Geografia, 2009
The study of glacial landforms and deposits is important, as it isdifficult to observe processes under modern glaciers and ice-sheets. Thus landscapes and sediments that are the product of present glaciation can give insight into processes that occurred ...
Carlos Córdova, João Santos
doaj   +3 more sources

Downward Mediterranean Cloudiness Beyond Little Ice Age Background Variability

Ocean-Land-Atmosphere Research
Cloudiness–sea interaction substantially influences Earth’s climate by shaping precipitation patterns and radiative budgets. However, our understanding of long-term variations in land-based cloud cover, spanning over decades, centuries, and more, remains
Nazzareno Diodato, Vinay Kumar, Gianni Bellocchi   +2 more
doaj   +1 more source