Results 51 to 60 of about 124,423 (252)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

The Palaeomeander at Vrakuňa, SW Slovakia and the historical Topography of the fording Point (Toll) on Žitný Ostrov Island / Vrakunský paleomeander a historická topografia mýtneho prechodu na Žitný ostrov [PDF]

Studia Historica Nitriensia
The Žitný ostrov Island (Hungarian: Csallóköz, German: Schüttinsel) located in SW Slovakia is separated from the main channel by the Malý Dunaj (Lesser or Little Danube), known as Čalov (Csalló) in the medieval period.
PIŠÚT, Peter, SZWARCZEWSZKI, Piotr, SMOLSKA, Ewa, RUSINKO, Adam   +3 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Post-little ice age glacial geomorphology of contrasting topographic settings at Skálafellsjökull, southeast Iceland

Journal of Maps
Glacial geomorphological mapping from the southern margin of Skálafellsjökull, southeast Iceland, depicts a topographically diverse mountainside, influencing glacier dynamics, landform formation and glacier retreat since the Little Ice Age maximum in ...
Sarah Walton, Robert Storrar, Naomi Holmes, Jonathan Bridge, Marek Ewertowski, Aleksandra Tomczyk, Andrew Jones   +6 more
doaj   +1 more source

The Toledo Mountains: A Resilient Landscape and a Landscape for Resilience? Hazards and Strategies in a Mid-Elevation Mountain Region in Central Spain

Quaternary, 2019
The Toledo Mountains are a mid-elevation mountain range that separates the Tagus and Guadiana basins in the central area of the Iberian Peninsula. The location of these mountains allows the development of typical Mediterranean vegetation with some ...
Reyes Luelmo-Lautenschlaeger, Sebastián Pérez-Díaz, Olivier Blarquez, César Morales-Molino, José Antonio López-Sáez   +4 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

The Little Ice Age, the climatic background of present-day warming in Europe

Cuadernos de Investigación Geográfica, 2018
The Little Ice Age (LIA) constitutes the coldest period of the last millennia in Europe. A wide range of natural and historical records show evidence of colder climate conditions between the 14th and 19th centuries, together with a higher frequency of ...
M. Oliva
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source