Results 61 to 70 of about 8,186,764 (283)

Reduction of glaciers of the South Chuya Range (Altai) since the maximum of the Little Ice Age

Лëд и снег
The extent of glaciation of the South Chuya Range in the LIA and the analysis of its subsequent gradual reduction were assessed. Based on interpretation of Corona, Landsat-7, Sentinel-2, World View-3 satellite images and analysis of field data, the ...
D. A. Ganyushkin, D. V. Bantcev, S. A. Griga, E. S. Derkach, O. V. Ostanin, Yu. A. Gorbunova,, V. A. Rasputina, K. V. Chistyakov   +7 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

DEVELOPMENT OF GLACIERS OF MOUNT ELBRUS AFTER THE LITTLE ICE AGE

Лëд и снег, 2015
SummaryThe results of remote monitoring of the greatest inEuropemountain glaciation of Elbrus are covered for 120 years by instrumental survey (1887–2007) and lichenometric survey in 1986.
E. A. Zolotarev, E. G. Kharkovets
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

"Little Ice Age" nivation activity in Northeast Greenland

, 1998
'Little Ice Age', Nivation, NE Greenland, Snowdrift, Niveo-fluvial, Niveo ...
Christiansen, Hanne Hvidtfeldt
core   +1 more source

Post-little ice age glacial geomorphology of contrasting topographic settings at Skálafellsjökull, southeast Iceland

Journal of Maps
Glacial geomorphological mapping from the southern margin of Skálafellsjökull, southeast Iceland, depicts a topographically diverse mountainside, influencing glacier dynamics, landform formation and glacier retreat since the Little Ice Age maximum in ...
Sarah Walton, Robert Storrar, Naomi Holmes, Jonathan Bridge, Marek Ewertowski, Aleksandra Tomczyk, Andrew Jones   +6 more
doaj   +1 more source

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab, Evelyn Alvarez, Roua Hamdi, Bingqing Zhang, Hayeun Ji, Niyati Jhaveri, Patrick Schindler, Pedro Sanchez, Pia S. Sperber, Tanja Schmitz‐Hübsch, Frederike C. Oertel, Nisa Vorasoot, Najib Kissani, Falko Böhringer, Jens Kuhle, Anne‐Katrin Pröbstel, Xiao‐Jun Ma, Péter Körtvelyessy, Patrick Waters, Friedemann Paul   +19 more
wiley   +1 more source

The Palaeomeander at Vrakuňa, SW Slovakia and the historical Topography of the fording Point (Toll) on Žitný Ostrov Island / Vrakunský paleomeander a historická topografia mýtneho prechodu na Žitný ostrov [PDF]

Studia Historica Nitriensia
The Žitný ostrov Island (Hungarian: Csallóköz, German: Schüttinsel) located in SW Slovakia is separated from the main channel by the Malý Dunaj (Lesser or Little Danube), known as Čalov (Csalló) in the medieval period.
PIŠÚT, Peter, SZWARCZEWSZKI, Piotr, SMOLSKA, Ewa, RUSINKO, Adam   +3 more
doaj   +1 more source