Results 41 to 50 of about 8,186,764 (283)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Dynamic LIA advances hastened the demise of small valley glaciers in central Svalbard
Arctic ScienceMost small land-terminating glaciers in Svalbard have experienced large recession since the Little Ice Age (LIA) and today are thin, cold, and largely inactive. This likely contrasts to their LIA conditions, but the observational record from that time is
Erik S. Mannerfelt +3 more
doaj +1 more source
Geophysical Research Letters, 2020 Acetylene is a short‐lived trace gas produced during combustion of fossil fuels, biomass, and biofuels. Biomass burning is likely the only major source of acetylene in the preindustrial atmosphere, making ice core acetylene a powerful tool for ...
Melinda R. Nicewonger +3 more
doaj +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
The definitive cause of little ice age temperatures
, 2022 Analysis of the Central England Instrumental Temperatures data set (1659-present) has provided the answer as to the cause of the decreased temperatures during the Little Ice Age (LIA) (and undoubtedly, also those of all other Ice Ages).
Burl Calvin Henry
core +1 more source
Downward Mediterranean Cloudiness Beyond Little Ice Age Background Variability
Ocean-Land-Atmosphere ResearchCloudiness–sea interaction substantially influences Earth’s climate by shaping precipitation patterns and radiative budgets. However, our understanding of long-term variations in land-based cloud cover, spanning over decades, centuries, and more, remains
Nazzareno Diodato +2 more
doaj +1 more source
ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function
FEBS Open Bio, EarlyView.Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley +5 more
wiley +1 more source
Little ice age clearly recorded in northern Greenland ice cores [PDF]
, 1998 Four ice cores drilled in the little investigated area of northern and northeastern Greenland were evaluated for their isotopic (δ18O) and chemical content.
Schwager, M. +10 more
core +2 more sources