Results 61 to 70 of about 122,239 (253)
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Fluctuating selection and rapid evolution of oaks during recent climatic transitions
Plants, People, PlanetSocietal Impact Statement The rapidity of evolutionary changes in trees and whether this pace is sufficient to cope with ongoing climatic change are hotly debated issues in ecology today.
Thomas Caignard +6 more
doaj +1 more source
The Little Ice Age, the climatic background of present-day warming in Europe
Cuadernos de Investigación Geográfica, 2018 The Little Ice Age (LIA) constitutes the coldest period of the last millennia in Europe. A wide range of natural and historical records show evidence of colder climate conditions between the 14th and 19th centuries, together with a higher frequency of ...
M. Oliva
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Mapping glaciers in Jotunheimen, South-Norway, during the "Little Ice Age" maximum [PDF]
The Cryosphere, 2009 The maximum glacier extent during the "Little Ice Age" (mid 18th century AD) in Jotunheimen, southern Norway, was mapped using remote sensing techniques.
S. Baumann, S. Winkler, L. M. Andreassen
doaj
Little Ice Age in Romania in the Vision of a Syrian Traveler
Present Environment and Sustainable Development, 2014 Archdeacon Paul of Aleppo of Damascus accompanied the Patriarch Macarios of Antioch, in Moldavia, Wallachia, Dobrogea for nearly seven years (1652-1659), just in time considered one of the coldest during the Little Ice Age, Maunder Minimum namely (1645 ...
Teodoreanu Elena
doaj +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Arctic, Antarctic, and Alpine Research, 2019 Glaciers have significant influence on hydrology, vegetation, and wildlife in mountainous regions, and are receding globally. To quantify the impacts of sustained glacier loss, we mapped a complete set of glacier areas from the Little Ice Age (LIA) using
Chelsea J. Martin-Mikle, Daniel B. Fagre
doaj +1 more source