Results 41 to 50 of about 2,495,910 (283)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

A New Biased Estimation Class to Combat the Multicollinearity in Regression Models: Modified Two--Parameter Liu Estimator

Computational Journal of Mathematical and Statistical Sciences
The multicollinearity problem occurrence of the explanatory variables affects the least-squares (LS) estimator seriously in the regression models. The multicollinearity adverse effects on the LS estimation are also investigated by many authors.
Mohamed Reda Abonazel
doaj   +1 more source

James Stein Estimator for the Beta Regression Model with Application to Heat-Treating Test and Body Fat Datasets

Axioms, 2023
The beta regression model (BRM) is used when the dependent variable may take continuous values and be bounded in the interval (0, 1), such as rates, proportions, percentages and fractions.
Muhammad Amin, Hajra Ashraf, Hassan S. Bakouch, Najla Qarmalah   +3 more
doaj   +1 more source

Identifying local influential observations in Liu estimator

, 2012
Identifying influential observations is an important step in the right direction of the linear regression model building process. Various influence measures based on different motivational arguments are designed to measure the influence of observations ...
陈建宝, Jahufer, Aboobacker, Chen, Jianbao   +2 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Liu Estimation Method in the Zero-Inflated Conway Maxwell Poisson Regression Model

Journal of Statistical Theory and Applications (JSTA)
The Zero-Inflated Conway-Maxwell Poisson Regression Model (ZICPRM) is developed specifically for overdispersed, underdispersed, and excessive zeros in the count data. The ZICMPRM is estimated by the maximum likelihood estimator (MLE).
Muhammad Amin, Bushra Ashraf, Syeda Maryam Siddiqa   +2 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

New estimators for the probit regression model with multicollinearity

Scientific African, 2023
The probit regression model (PRORM) aims to model a binary response with one or more explanatory variables. The parameter of the PRORM is estimated using an estimation method called the maximum likelihood (ML), like a logistic model.
Mohamed R. Abonazel, Issam Dawoud, Fuad A. Awwad, Elsayed Tag-Eldin   +3 more
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Enhancing the accuracy of modeling highly multicollinear CO2 emission data using a novel generalized Poisson Liu regression method

AIP Advances
Count data often exhibit dispersion patterns that the standard Poisson regression model struggles to handle, particularly in cases of overdispersion or underdispersion. The generalized Poisson regression model (GPRM) provides a more flexible alternative,
Ali T. Hammad, Alexis Habineza, Ahmed M. Gemeay, Fatimah A. Almulhim   +3 more
doaj   +1 more source