Results 41 to 50 of about 19,774 (283)

Almost Unbiased Liu Principal Component Estimator in the Presence of Multicollinearity and Autocorrelation [PDF]

The Egyptian Statistical Journal, 2020
In this article , a new class of estimator called the almost Unbiased Liu Principal Component Estimator (AULPCR) for the multiple linear regression model with autocorrelated error in the presence of multicollinearity problem will be suggested .
Ahmed A. E., Amal H. A., Hassan M. Ali
doaj   +1 more source

Kibria–Lukman-Type Estimator for Regularization and Variable Selection with Application to Cancer Data

Mathematics, 2023
Following the idea presented with regard to the elastic-net and Liu-LASSO estimators, we proposed a new penalized estimator based on the Kibria–Lukman estimator with L1-norms to perform both regularization and variable selection.
Adewale Folaranmi Lukman, Jeza Allohibi, Segun Light Jegede, Emmanuel Taiwo Adewuyi, Segun Oke, Abdulmajeed Atiah Alharbi   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Performance of some estimators for the multicollinear logistic regression model: theory, simulation, and applications

Research in Statistics
This article proposes some new estimators, namely Stein’s estimators for ridge regression and Kibria and Lukman estimator and compares their performance with some existing estimators, namely maximum likelihood estimator (MLE), ridge regression estimator,
Md Ariful Hoque, B. M. Golam Kibria
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

A Modified New Two-Parameter Estimator in a Linear Regression Model

Modelling and Simulation in Engineering, 2019
The literature has shown that ordinary least squares estimator (OLSE) is not best when the explanatory variables are related, that is, when multicollinearity is present. This estimator becomes unstable and gives a misleading conclusion.
Adewale F. Lukman, Kayode Ayinde, Sek Siok Kun, Emmanuel T. Adewuyi   +3 more
doaj   +1 more source

Liu Estimates and Influence Analysis in Regression Models with Stochastic Linear Restrictions and AR (1) Errors [PDF]

Journal of Sciences, Islamic Republic of Iran, 2019
In the linear regression models with AR (1) error structure when collinearity exists, stochastic linear restrictions or modifications of biased estimators (including Liu estimators) can be used to reduce the estimated variance of the regression ...
Hoda Mohammadi, Abdolrahman Rasekh
doaj   +1 more source

An alternative stochastic restricted Liu estimator in linear regression

, 2009
Liu estimator, Mixed estimator, Stochastic restricted Liu estimator, Mean squared error matrix,
Hu Yang, Jianwen Xu
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source