Results 51 to 60 of about 164,145 (281)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A New Biased Estimation Class to Combat the Multicollinearity in Regression Models: Modified Two--Parameter Liu Estimator

Computational Journal of Mathematical and Statistical Sciences
The multicollinearity problem occurrence of the explanatory variables affects the least-squares (LS) estimator seriously in the regression models. The multicollinearity adverse effects on the LS estimation are also investigated by many authors.
Mohamed Reda Abonazel
doaj   +1 more source

Modified Liu estimator to address the multicollinearity problem in regression models: A new biased estimation class

Scientific African, 2022
The multicollinearity problem occurrence of the explanatory variables affects the least-squares (LS) estimator seriously in the regression models. The multicollinearity adverse effects on the LS estimation are also investigated by lots of authors.
Issam Dawoud, Mohamed R. Abonazel, Fuad A. Awwad   +2 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

New Robust Estimators for Handling Multicollinearity and Outliers in the Poisson Model: Methods, Simulation and Applications

Axioms, 2022
The Poisson maximum likelihood (PML) is used to estimate the coefficients of the Poisson regression model (PRM). Since the resulting estimators are sensitive to outliers, different studies have provided robust Poisson regression estimators to alleviate ...
Issam Dawoud, Fuad A. Awwad, Elsayed Tag Eldin, Mohamed R. Abonazel   +3 more
doaj   +1 more source

Depth weighted scatter estimators [PDF]

, 2005
General depth weighted scatter estimators are introduced and investigated. For general depth functions, we find out that these affine equivariant scatter estimators are Fisher consistent and unbiased for a wide range of multivariate distributions, and ...
Cui, Hengjian, Zuo, Yijun
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Liu Estimation Method in the Zero-Inflated Conway Maxwell Poisson Regression Model

Journal of Statistical Theory and Applications (JSTA)
The Zero-Inflated Conway-Maxwell Poisson Regression Model (ZICPRM) is developed specifically for overdispersed, underdispersed, and excessive zeros in the count data. The ZICMPRM is estimated by the maximum likelihood estimator (MLE).
Muhammad Amin, Bushra Ashraf, Syeda Maryam Siddiqa   +2 more
doaj   +1 more source

Kibria-Lukman Estimator for General Linear Regression Model with AR(2) Errors: A Comparative Study with Monte Carlo Simulation

Journal of New Theory, 2022
The sensitivity of the least-squares estimation in a regression model is impacted by multicollinearity and autocorrelation problems. To deal with the multicollinearity, Ridge, Liu, and Ridge-type biased estimators have been presented in the statistical ...
Tuğba Söküt Açar
doaj   +1 more source