Results 61 to 70 of about 164,145 (281)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Enhancing the accuracy of modeling highly multicollinear CO2 emission data using a novel generalized Poisson Liu regression method

AIP Advances
Count data often exhibit dispersion patterns that the standard Poisson regression model struggles to handle, particularly in cases of overdispersion or underdispersion. The generalized Poisson regression model (GPRM) provides a more flexible alternative,
Ali T. Hammad, Alexis Habineza, Ahmed M. Gemeay, Fatimah A. Almulhim   +3 more
doaj   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

High Dimensional Semiparametric Gaussian Copula Graphical Models

, 2012
In this paper, we propose a semiparametric approach, named nonparanormal skeptic, for efficiently and robustly estimating high dimensional undirected graphical models.
Han, Fang, Lafferty, John, Liu, Han, Wasserman, Larry, Yuan, Ming   +4 more
core   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Modelling Instance-Level Annotator Reliability for Natural Language Labelling Tasks

, 2019
When constructing models that learn from noisy labels produced by multiple annotators, it is important to accurately estimate the reliability of annotators.
Ananiadou, Sophia, Li, Maolin, Mu, Tingting, Myrman, Arvid Fahlström   +3 more
core   +1 more source

A new Poisson Liu Regression Estimator: method and application [PDF]

Journal of Applied Statistics, 2019
This paper considers the estimation of parameters for the Poisson regression model in the presence of high, but imperfect multicollinearity. To mitigate this problem, we suggest using the Poisson Liu Regression Estimator (PLRE) and propose some new approaches to estimate this shrinkage parameter.
Muhammad Qasim, B. M. G. Kibria, Kristofer Månsson, Pär Sjölander   +3 more
openaire   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

New Versions of Liu-type Estimator in Weighted and non-weighted Mixed Regression Model

مجلة بغداد للعلوم, 2020
This paper considers and proposes new estimators that depend on the sample and on prior information in the case that they either are equally or are not equally important in the model.
Mustafa Ismaeel Naif Alheety
doaj  

Efficient Monte Carlo for high excursions of Gaussian random fields

, 2012
Our focus is on the design and analysis of efficient Monte Carlo methods for computing tail probabilities for the suprema of Gaussian random fields, along with conditional expectations of functionals of the fields given the existence of excursions above ...
Adler, Robert J., Blanchet, Jose H., Liu, Jingchen   +2 more
core   +1 more source