Results 61 to 70 of about 4,819,578 (314)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

A New Conway Maxwell–Poisson Liu Regression Estimator—Method and Application

Journal of Mathematics, 2022
Poisson regression is a popular tool for modeling count data and is applied in medical sciences, engineering and others. Real data, however, are often over or underdispersed, and we cannot apply the Poisson regression. To overcome this issue, we consider
Muhammad Nauman Akram, Muhammad Amin, Faiza Sami, Adam Braima Mastor, Omer Mohamed Egeh, Abdisalam Hassan Muse   +5 more
doaj   +1 more source

Generalized Kibria-Lukman Estimator: Method, Simulation, and Application

Frontiers in Applied Mathematics and Statistics, 2022
In the linear regression model, the multicollinearity effects on the ordinary least squares (OLS) estimator performance make it inefficient. To solve this, several estimators are given. The Kibria-Lukman (KL) estimator is a recent estimator that has been
Issam Dawoud, Mohamed R. Abonazel, Fuad A. Awwad   +2 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

On the restricted almost unbiased Liu estimator in the logistic regression model [PDF]

, 2017
It is known that when the multicollinearity exists in the logistic regression model, variance of maximum likelihood estimator is unstable. As a remedy, in the context of biased shrinkage Liu estimation, Chang introduced an almost unbiased Liu estimator ...
Jibo Wu, Yasin Asar, M. Arashi
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Liu Estimation Method in the Zero-Inflated Conway Maxwell Poisson Regression Model

Journal of Statistical Theory and Applications (JSTA)
The Zero-Inflated Conway-Maxwell Poisson Regression Model (ZICPRM) is developed specifically for overdispersed, underdispersed, and excessive zeros in the count data. The ZICMPRM is estimated by the maximum likelihood estimator (MLE).
Muhammad Amin, Bushra Ashraf, Syeda Maryam Siddiqa   +2 more
doaj   +1 more source

New Robust Estimators for Handling Multicollinearity and Outliers in the Poisson Model: Methods, Simulation and Applications

Axioms, 2022
The Poisson maximum likelihood (PML) is used to estimate the coefficients of the Poisson regression model (PRM). Since the resulting estimators are sensitive to outliers, different studies have provided robust Poisson regression estimators to alleviate ...
Issam Dawoud, Fuad A. Awwad, Elsayed Tag Eldin, Mohamed R. Abonazel   +3 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Enhancing the accuracy of modeling highly multicollinear CO2 emission data using a novel generalized Poisson Liu regression method

AIP Advances
Count data often exhibit dispersion patterns that the standard Poisson regression model struggles to handle, particularly in cases of overdispersion or underdispersion. The generalized Poisson regression model (GPRM) provides a more flexible alternative,
Ali T. Hammad, Alexis Habineza, Ahmed M. Gemeay, Fatimah A. Almulhim   +3 more
doaj   +1 more source