Results 41 to 50 of about 1,671,583 (304)

Interference Between Enteric Viruses and Live-Attenuated Rotavirus Vaccine Virus in a Healthy Australian Birth Cohort

, 2023
Rotavirus vaccines have reduced effectiveness in high mortality settings. Interference between enteric viruses and live-attenuated oral vaccine strains may be a factor.
Asmaa El-Heneidy, Keith Grimwood, Stephen B Lambert, Robert S Ware, El-Heneidy, Asmaa, Grimwood, Keith, Lambert, Stephen B, Ware, Robert S   +7 more
core   +1 more source

Egy virulencia regulátor mutáns Salmonella enterica törzs mint kereszt-immunitást biztosító orális vakcina jelölt vizsgálata = Investigation of a virulence regulator mutant strain of Salmonella enterica as a candidate for live oral vaccine providing cross-immunity [PDF]

, 2008
Kutatásaink során egy Salmonella rfaH mutánst mint potenciális vakcina jelöltet vizsgáltunk több aspektusból. Mivel az RfaH fehérje egy transzkripciós regulátor, vizsgáltuk, hogy mely virulencia faktorokra kifejtett hatása okozza a vakcina törzs ...
Nagy, Gábor
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Oronasal or Intramuscular Immunization with a Thermo-Attenuated ASFV Strain Provides Full Clinical Protection against Georgia 2007/1 Challenge

Viruses, 2022
African swine fever (ASF) is a contagious viral disease of suids that induces high mortality in domestic pigs and wild boars. Given the current spread of ASF, the development of a vaccine is a priority.
Olivier Bourry, Evelyne Hutet, Mireille Le Dimna, Pierrick Lucas, Yannick Blanchard, Amélie Chastagner, Frédéric Paboeuf, Marie-Frédérique Le Potier   +7 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Seroconversion of a Thermostable live Attenuated Lentogenic Strain Newcastle Disease Vaccine (Local isolate) in Chicken

, 2017
Vaccine was prepared by using the isolate, exposed to 430 C for 12 days. The vaccination was performed in two thousand four hundred breeder flocks (Banoraja) in 3 different flocks @106.5 EID50 per bird oronasally at the age of day 5 (primary ...
U Biswas, L. Sharma, A Chatterjee, P.S. Jana, L Sharma, U. Biswas, R. Pandey, C. Guha, R Pandey, A. Chatterjee, C Guha, PS Jana   +11 more
core   +1 more source

Malaria vaccine research and development: the role of the WHO MALVAC committee. [PDF]

, 2013
The WHO Malaria Vaccine Advisory Committee (MALVAC) provides advice to WHO on strategic priorities, activities and technical issues related to global efforts to develop vaccines against malaria.
Vasee S Moorthy, Graham V Brown, Geoffrey AT Targett, Targett, Geoffrey AT, Brown, GV, Moorthy, Vasee S, Brown, Graham V, Geoffrey AT Targett, Moorthy, VS, Targett, GA   +9 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Tuberculosis vaccine: pipeline approaches and future prospective [PDF]

, 2011
Tuberculosis (TB), despite anti-mycobacterial therapies and vaccine, is a deadly infectious disease with about 12 million incident cases worldwide. Existing Bacillus Calmette-Guérin (BCG) vaccine is unquestionably inexpensive, safe and effective ...
Poonam Yadav, Ankita Singh, Ankita Singh, L K Dwivedi, Poonam Yadav   +4 more
core   +1 more source

Effect Modification of Cigarette Smoking on the Relationship between Post‐traumatic Stress Disorder, Other Mental Health Conditions and Rheumatoid Arthritis Risk: A Large Case‐Control Study in U.S. Veterans

Arthritis Care &Research, Accepted Article.
Objective We examined associations of post‐traumatic stress disorder (PTSD) and other mental health disorders (OMH) with rheumatoid arthritis (RA), accounting for effects of smoking. Methods We conducted a matched case‐control study, identifying incident RA cases and controls using national Veteran Health Administration data (2006‐2019).
Kelsey Coziahr, Harlan Sayles, Tate M. Johnson, Joshua F. Baker, Punyasha Roul, Grant W. Cannon, Gary A. Kunkel, Katherine D. Wysham, Gail S. Kerr, Amir A. Razmjou, Isaac Smith, Jennifer L. Barton, Maria I. Danila, Jonathan S. Richards, Bryant R. England, Ted R. Mikuls   +15 more
wiley   +1 more source