Results 231 to 240 of about 43,630 (288)

Monovalent glycoconjugates of sulforaphane prevent inflammation induced by lipopolysaccharide in human dendritic cells by inhibiting NF‐ĸB signalling pathway

British Journal of Pharmacology, EarlyView.
Background and Purpose Sulforaphane (SFN) has notable health benefits but faces challenges due to its poor solubility and delivery. This study investigates SFN‐glycoconjugates effects on lipopolysaccharide (LPS)‐induced inflammation in dendritic cells (DCs). With the aiming to enhance their therapeutic potential against inflammatory diseases.
Camila Leiva‐Castro, Ana Maria Múnera‐Rodríguez, Macarena Martínez‐Bailén, Ana Teresa Carmona, Soledad López‐Enríquez, Francisca Palomares   +5 more
wiley   +1 more source

Plugging gaps in payment systems: Evidence from the take‐up of new Medicare billing codes

Contemporary Economic Policy, EarlyView.
Abstract We analyze the introduction of new Medicare billing codes for Chronic Care Management (CCM) and Transitional Care Management (TCM). We first show that new code take‐up occurs gradually and varies across space and physician characteristics. Second, we study how the codes correlate with other services, focusing on two case studies.
Jeffrey Clemens, Jonathan M. Leganza, Alex Masucci   +2 more
wiley   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Vaccination in Multiple Myeloma: Challenges and Strategies

European Journal of Haematology, EarlyView.
ABSTRACT Background Multiple myeloma (MM) is a hematological malignancy characterized by profound immunosuppression resulting from both disease‐related mechanisms and treatment‐induced immune dysfunction. This compromised immune status markedly increases susceptibility to infections, a leading cause of morbidity and mortality in MM patients.
Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Santino Caserta, Francesco Mendicino, Fortunato Morabito, Massimo Gentile   +10 more
wiley   +1 more source

Intratumoural tigilanol tiglate in the multicentre treatment of equine sarcoids and cutaneous melanomas

Equine Veterinary Journal, EarlyView.
Abstract Background Intralesional chemotherapeutic administration represents an important treatment option for equine cutaneous neoplasia. Tigilanol‐tiglate (TT), a novel molecule extracted from Fontainea picrosperma, an Australian rainforest plant, is registered for intratumoural treatment of canine MCT, leading to rapid oncosis and tumour slough ...
Raphael Labens, Corey Saba, Jarred Williams, Anna Hollis, Jos Ensink, Eduard Jose‐Cunilleras, Mireia Jordana‐Garcia, Kerstin Bergvall, Mick Ruppin, Frank Condon, Caroline Spelta, Yvonne Elce, Thomas De Ridder, John Morton, Cassandra McGee, Paul Reddell   +15 more
wiley   +1 more source

Neonatal BCG Vaccination Decreases Eczema Incidence at 5 years: The MIS BAIR Randomised Controlled Trial

Allergy, EarlyView.
Laure F. Pittet, Nicole L. Messina, Kate L. Francis, Susan Donath, Katie L. Flanagan, Emily K. Forbes, Kaya Gardiner, Roderic J. Phillips, Anne‐Louise Ponsonby, Roy Robins‐Browne, Frank Shann, Mike South, Peter Vuillermin, Dan Casalaz, Nigel Curtis, On the behalf of the Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR) Group   +15 more
wiley   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

Adsorption of antigen to polymeric nanoparticles enhances cytotoxic T‐cell responses and anti‐tumor immunity by targeting conventional type 1 dendritic cells

Immunology &Cell Biology, EarlyView.
Therapeutic cancer vaccines require CD8+ T‐cell activation for efficacy. This response can be enhanced by rationally designing polymeric nanoparticle adjuvants. The importance of antigen location for the adjuvanticity of polymeric nanoparticles has not been fully resolved.
Jorge Huete‐Carrasco, Jingjing Zhu, Benoit J Van den Eynde, Christian Thomas Mayer, Tim Sparwasser, Ross W Ward, Ed C Lavelle   +6 more
wiley   +1 more source

A Live, Attenuated Dengue Virus Type 1 Vaccine Candidate with a 30-Nucleotide Deletion in the 3′ Untranslated Region Is Highly Attenuated and Immunogenic in Monkeys

, 2002
Stephen S. Whitehead, Barry Falgout, Kathryn A. Hanley, Joseph E. Blaney, Lewis Markoff, Brian R. Murphy   +5 more
openalex   +1 more source

CD4+ tissue‐resident memory T cells and their role in immunity

Immunology &Cell Biology, EarlyView.
In this article, we review and discuss the role of CD4+ tissue‐resident memory T (TRM) cells and their role in immune protection in tissues, such as the lungs, by facilitating pathogen clearance through cytokine production and local immune interactions.
Margarida Kirkby, Marc Veldhoen
wiley   +1 more source