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Live attenuated tetravalent dengue vaccine
Vaccine, 2000The development of a live attenuated tetravalent dengue vaccine is currently the best strategy to obtain a vaccine against dengue viruses. The Mahidol University group developed candidate live attenuated vaccines by attenuation through serial passages in certified primary cell cultures.
N, Bhamarapravati, Y, Sutee
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Immunization with Live Attenuated Poliovirus Vaccine
Archives of Pediatrics & Adolescent Medicine, 1961Live attenuated poliovirus vaccine was administered to 400 newborn infants during a three-month period (October, 1959, to January, 1960). This study was designed to obtain information which might provide answers to the following questions. Would the ingestion of larger doses permit enough of the vaccine viruses regularly to pass the "acid barrier" of ...
S, KRUGMAN +5 more
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A Trial With Live Attenuated Rubella Vaccine
Archives of Pediatrics & Adolescent Medicine, 1968CONTROLLED trials of a high passage rubella virus strain conducted by Meyer et al in institutionalized human subjects 1 indicated that the virus was attenuated, immunogenic, and did not spread from vaccinees to others. The present investigation was undertaken to extend these observations in younger institutionalized subjects.
M L, Lepow +3 more
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Live attenuated influenza vaccine
2008The development of the live, attenuated influenza vaccine (LAIV), based on the cold-adapted (ca), attenuated ca A/Ann Arbor/6/60 and ca B/Ann Arbor/1/66 backbones, has spanned several decades. The vaccine contains three vaccine strains, two attenuated influenza A strains and one attenuated influenza B strain; these vaccine strains are genetic ...
Harry Greenberg, George Kemble
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An Attenuated Live Virus Vaccine for Myxomatosis
Nature, 1964MYXOMATOSIS has been recognized as a virus disease since 18981. Although the disease is uniformly fatal, efforts to develop an effective, practical method of prevention have met with indifferent success.
D G, MCKERCHER, J K, SAITO
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Live Attenuated Influenza Vaccine in Children
Seminars in Pediatric Infectious Diseases, 2006Live attenuated influenza vaccine (LAIV) offers a novel approach to influenza vaccination and is approved for healthy individuals 5 to 49 years of age. In placebo-controlled studies in children, LAIV was 73 to 93 percent efficacious, and protection lasted more than 12 months.
Christopher S, Ambrose +2 more
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Vaccination with Live Attenuated Measles Virus
Archives of Pediatrics & Adolescent Medicine, 1962Introduction Isolation of the virus of measles in human tissue culture and its subsequent adaptation to growth in embryonated eggs and chick embryo cell culture by Enders and his colleagues 1-3 has led to the rapid development in the United States of vaccines suitable for use in the immunoprophylaxis of this disease.
R B, HORNICK +2 more
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A live attenuated human rotavirus vaccine
Drugs of Today, 2007Rotavirus infections are the leading cause of severe gastroenteritis in young children worldwide. This review provides a summary of the development of a live oral rotavirus vaccine, Rotarix (GlaxoSmithKline, Rixensart, Belgium) developed from a single protective G1P[8] human strain.
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Live, Attenuated Rubella-Virus Vaccine
New England Journal of Medicine, 1968HIGH priority is being given in the United States and Europe to the development of an effective live, attenuated rubella (German-measles) virus vaccine.
M R, Hilleman +3 more
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Live Attenuated Varicella-Zoster Vaccine
Clinical Infectious Diseases, 1980Varicella-zoster (VZ) virus causes two diseases, varicella and zoster. Because it was recognized that, after varicella, latent VZ virus persisted in the host and because varicella was thought to be a milde disease, there was little impetus in North America to develop a live VZ vaccine.
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