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Vaccination with Live Attenuated Measles Virus
Archives of Pediatrics & Adolescent Medicine, 1962Introduction Isolation of the virus of measles in human tissue culture and its subsequent adaptation to growth in embryonated eggs and chick embryo cell culture by Enders and his colleagues 1-3 has led to the rapid development in the United States of vaccines suitable for use in the immunoprophylaxis of this disease.
R B, HORNICK +2 more
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Live attenuated influenza vaccine
2008The development of the live, attenuated influenza vaccine (LAIV), based on the cold-adapted (ca), attenuated ca A/Ann Arbor/6/60 and ca B/Ann Arbor/1/66 backbones, has spanned several decades. The vaccine contains three vaccine strains, two attenuated influenza A strains and one attenuated influenza B strain; these vaccine strains are genetic ...
Harry Greenberg, George Kemble
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Live attenuated tetravalent dengue vaccine
Vaccine, 2000The development of a live attenuated tetravalent dengue vaccine is currently the best strategy to obtain a vaccine against dengue viruses. The Mahidol University group developed candidate live attenuated vaccines by attenuation through serial passages in certified primary cell cultures.
N, Bhamarapravati, Y, Sutee
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A Trial With Live Attenuated Rubella Vaccine
Archives of Pediatrics & Adolescent Medicine, 1968CONTROLLED trials of a high passage rubella virus strain conducted by Meyer et al in institutionalized human subjects 1 indicated that the virus was attenuated, immunogenic, and did not spread from vaccinees to others. The present investigation was undertaken to extend these observations in younger institutionalized subjects.
M L, Lepow +3 more
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Live Attenuated Vaccine Vectors
International Journal of Technology Assessment in Health Care, 1994AbstractSeveral different live attenuated vaccine vectors currently are under development. These vaccines are composed of living viruses or bacteria that are innocuous to the host but can replicate in host tissues and induce immune responses. The genes encoding foreign antigens can be inserted into these vectors to produce multivalent vaccines that ...
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Immunization with Live Attenuated Poliovirus Vaccine
Archives of Pediatrics & Adolescent Medicine, 1961Live attenuated poliovirus vaccine was administered to 400 newborn infants during a three-month period (October, 1959, to January, 1960). This study was designed to obtain information which might provide answers to the following questions. Would the ingestion of larger doses permit enough of the vaccine viruses regularly to pass the "acid barrier" of ...
S, KRUGMAN +5 more
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An Attenuated Live Virus Vaccine for Myxomatosis
Nature, 1964MYXOMATOSIS has been recognized as a virus disease since 18981. Although the disease is uniformly fatal, efforts to develop an effective, practical method of prevention have met with indifferent success.
D G, MCKERCHER, J K, SAITO
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Live Attenuated Influenza Vaccine in Children
Seminars in Pediatric Infectious Diseases, 2006Live attenuated influenza vaccine (LAIV) offers a novel approach to influenza vaccination and is approved for healthy individuals 5 to 49 years of age. In placebo-controlled studies in children, LAIV was 73 to 93 percent efficacious, and protection lasted more than 12 months.
Christopher S, Ambrose +2 more
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Live-attenuated chikungunya virus vaccine
CellAlthough Chikungunya fever does not a have a high fatality rate (
Lisa F P, Ng, Laurent, Rénia
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Live, Attenuated Rubella-Virus Vaccine
New England Journal of Medicine, 1968HIGH priority is being given in the United States and Europe to the development of an effective live, attenuated rubella (German-measles) virus vaccine.
M R, Hilleman +3 more
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