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Live Attenuated Influenza Vaccine - A review
Journal of preventive medicine and hygiene, 2011Owing to the variability of influenza viruses, vaccine composition needs to be up-dated annually. As many variables can influence their efficacy, vaccines are still considered ?sub-optimal?. Many studies have been carried out in recent years to improve vaccines.
GASPARINI, ROBERTO +3 more
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Live Attenuated Influenza Vaccine
2014Cold-adapted Ann Arbor based live attenuated influenza vaccine (LAIV) has been available in the USA since 2003. The vaccine is efficacious against influenza infection. Features of LAIV include: easy administration suitable for mass immunization, cross-reactivity to drifted strains for broader coverage, and establishment of herd immunity for control of ...
Kanta Subbarao, Hong Jin
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Live attenuated anticoccidial vaccines for chickens
Trends in Parasitology, 2023Chicken coccidiosis, caused by infection with single or multiple Eimeria species, results in significant economic losses to the global poultry industry. Over the past decades, considerable efforts have been made to generate attenuated Eimeria strains, and the use of live attenuated anticoccidial vaccines for disease prevention has achieved tremendous ...
Qing Liu +4 more
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Live Attenuated Vaccine Vectors
International Journal of Technology Assessment in Health Care, 1994AbstractSeveral different live attenuated vaccine vectors currently are under development. These vaccines are composed of living viruses or bacteria that are innocuous to the host but can replicate in host tissues and induce immune responses. The genes encoding foreign antigens can be inserted into these vectors to produce multivalent vaccines that ...
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Live attenuated influenza vaccine
2008The development of the live, attenuated influenza vaccine (LAIV), based on the cold-adapted (ca), attenuated ca A/Ann Arbor/6/60 and ca B/Ann Arbor/1/66 backbones, has spanned several decades. The vaccine contains three vaccine strains, two attenuated influenza A strains and one attenuated influenza B strain; these vaccine strains are genetic ...
Harry B. Greenberg +2 more
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Vaccination with Live Attenuated Measles Virus
Archives of Pediatrics & Adolescent Medicine, 1962Introduction Isolation of the virus of measles in human tissue culture and its subsequent adaptation to growth in embryonated eggs and chick embryo cell culture by Enders and his colleagues 1-3 has led to the rapid development in the United States of vaccines suitable for use in the immunoprophylaxis of this disease.
Richard B. Hornick +2 more
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A Trial With Live Attenuated Rubella Vaccine
Archives of Pediatrics & Adolescent Medicine, 1968CONTROLLED trials of a high passage rubella virus strain conducted by Meyer et al in institutionalized human subjects 1 indicated that the virus was attenuated, immunogenic, and did not spread from vaccinees to others. The present investigation was undertaken to extend these observations in younger institutionalized subjects.
D. D. Hostetler +3 more
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Live attenuated tetravalent dengue vaccine
Vaccine, 2000The development of a live attenuated tetravalent dengue vaccine is currently the best strategy to obtain a vaccine against dengue viruses. The Mahidol University group developed candidate live attenuated vaccines by attenuation through serial passages in certified primary cell cultures.
Y Sutee, Natth Bhamarapravati
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Live Attenuated Viral Vaccines
2014The history of vaccination using live viruses extends through several centuries and is directly intertwined with the elimination of smallpox (variola major, Plotkin and Plotkin 2004). The word vaccine comes from the Latin “vaccinus” meaning “of cows”—an adjective joining variola (smallpox) and vaccinae to form cowpox (variola vaccinae, Jenner 1798 ...
Kuldip Sra +3 more
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An Attenuated Live Virus Vaccine for Myxomatosis
Nature, 1964MYXOMATOSIS has been recognized as a virus disease since 18981. Although the disease is uniformly fatal, efforts to develop an effective, practical method of prevention have met with indifferent success.
J. K. Saito, D. G. Mckercher
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