Results 91 to 100 of about 3,370,678 (301)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Retrospective cohort study on cumulative live birth rate of in vitro fertilization/intracytoplasmic sperm injection after multiple complete cycles in patients with diminished ovarian reserve

BMC Pregnancy and Childbirth
Background Diminished ovarian reserve refers to the decrease in the quantity and quality of oocytes in the ovary which may cause poor fertility outcomes even with the help of assisted reproductive techniques. Most patients will undergo multiple cycles of
Sisi Xi, Xiuli Yang, Jing Shang, Qing Xue   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Birth weight differences between preterm stillbirths and live births: analysis of population-based studies from the U.S. and Sweden

BMC Pregnancy and Childbirth, 2012
Background Many stillbirths show evidence of fetal growth restriction, and most occur at preterm gestational age. The objective of this study is to compare birth weights at preterm gestational ages between live births and stillbirths, and between those ...
Zhang Xun, Joseph KS, Cnattingius Sven, Kramer Michael S   +3 more
doaj   +1 more source

Down syndrome (DS) live birth rates.

, 2013
The Taiwanese DS live birth ratio dropped from 48.74% of all fetuses with DS in 2001 to 25.88% in 2006, when first-trimester DS screening was widely introduced.
Ming-Wei Lin (383487), Chia-Jung Hsieh (461348), Sheng-Wen Steven Shaw (461350), Chien-Nan Lee (348009), Yi-Li Chen (461349), Shin-Yu Lin (348006), Pau-Chung Chen (130563)   +6 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Regression analysis for the live birth rate per thaw cycle.

, 2018
Regression analysis for the live birth rate per thaw cycle.
Shuang Jing (6009062), Guang-Xiu Lu (4746882), Ge Lin (276102), Hui Guo (110581), Chang-Fu Lu (4746888), Fei Gong (3173460), Yi-Fan Gu (4746885), Qin-Wei Zhou (4746876), Li Xu (108702)   +8 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Live birth rates in In vitro fertilization cycles with oocytes containing smooth endoplasmic reticulum aggregates and normal oocytes

Journal of Human Reproductive Sciences, 2019
Aims: The aims of this study were to compare the live birth, embryological and pregnancy outcomes after intracytoplasmic sperm injection (ICSI) in patients who have oocytes with smooth endoplasmic reticulum aggregates (SERa+ cycles) and patients with ...
Sumana Gurunath, Reeta Biliangady, Uma Maheshwari Sundhararaj, Ambika Gangadharswamy, Swathi Gundlapalli, G Murali Mohan Reddy   +5 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source