Results 51 to 60 of about 2,422,081 (245)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Live birth rate after human chorionic gonadotropin priming in vitro maturation in women with polycystic ovary syndrome

Journal of Ovarian Research, 2018
Background In vitro maturation (IVM) has some advantages over conventional in vitro fertilization (IVF), particularly in polycystic ovary syndrome (PCOS) where the risk of ovarian hyperstimulation is high. We studied the live birth rate in a large series
V. N. A. Ho, T. D. Pham, A. H. Le, T. M. Ho, L. N. Vuong   +4 more
doaj   +1 more source

Mitochondrial DNA Content May Not Be a Reliable Screening Biomarker for Live Birth After Single Euploid Blastocyst Transfer

Frontiers in Endocrinology, 2021
An increasing number of studies have related the mitochondrial DNA (mtDNA) content to embryo viability and transfer outcomes. However, previous studies have focused more on the relationship between mtDNA and embryo implantation, few studies have studied ...
Xuanyou Zhou, Xuanyou Zhou, Xueli Liu, Xueli Liu, Weihui Shi, Weihui Shi, Mujin Ye, Mujin Ye, Songchang Chen, Songchang Chen, Songchang Chen, Chenming Xu, Chenming Xu, Chenming Xu   +13 more
doaj   +1 more source

Changes in the live birth profile in Henan, China: A hospital registry‐based study

, 2022
BACKGROUND: Preterm complications and neonatal asphyxia are the leading causes of death in those under 5 years of age. However, little information exists for the province of Henan, China. The purpose of this study was to explore changes in the live birth
Shihong Cui, Xu, Falin, Chen, Xi, Zhang, S., Cui, Shihong, Wang, Xiaoyang,, Lei Xia, Chen, X., Aiqing Liu, Zhang, R. L., Shan Zhang, Gao, L., Xia, Lei, Liu, A. Q., Ding, Wenjun, Ruili Zhang, Changlian Zhu, Zhang, X. L., Zhu, Changlian,, Xiaoli Zhang, Xu, F. L., Gao, Liang, Liu, Aiqing, Xi Chen, Zhang, Xiaoli, Liang Gao, Wang, Xiaoyang, Xiaoyang Wang, Zhang, Shan, Cui, S. H., Wenjun Ding, Falin Xu, Li, Bingbing, Zhu, Changlian, Ding, W. J., Xia, L., Zhang, Ruili, Bingbing Li, Li, B. B.   +38 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Effect of race and ethnicity on utilization and outcomes of assisted reproductive technology in the USA

Reproductive Biology and Endocrinology, 2017
Background The purpose of this study was to determine the utilization and live birth rates of assisted reproductive technology (ART) modalities among various racial and ethnic groups in recent years.
Alice J. Shapiro, Sarah K. Darmon, David H. Barad, David F. Albertini, Norbert Gleicher, Vitaly A. Kushnir   +5 more
doaj   +1 more source

Levels and Correlates of Non-Adherence to WHO Recommended Inter-Birth Intervals in Rufiji, Tanzania. [PDF]

, 2012
Poorly spaced pregnancies have been documented worldwide to result in adverse maternal and child health outcomes. The World Health Organization (WHO) recommends a minimum inter-birth interval of 33 months between two consecutive live births in order to ...
Honorati Masanja, Bietsch Kristin, Sigilbert Mrema, Exavery, Amon, Shamte, Amri, Godfrey Mbaruku, Dominic Mosha, Masanja Honorati, Exavery Amon, Shamte Amri, Mrema Sigilbert, Amon Exavery, Mosha Dominic, Amri Shamte, Mrema, Sigilbert, Mbaruku Godfrey, Masanja, Honorati, Mbaruku, Godfrey, Kristin Bietsch, Mosha, Dominic, Bietsch, Kristin   +20 more
core   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source