Results 71 to 80 of about 168,951 (306)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Observational cohort study exploring MediEmo smartphone application use, live birth, and in vitro fertilization treatment return rates

F&S Reports
Objective: To explore the associations between the use of the MediEmo smartphone application and in vitro fertilization (IVF) live birth and treatment return rates.
Isla F. Robertson, D.M., China R. Harrison, Ph.D., Richard D. Morey, Ph.D., Jacky Boivin, Ph.D., Ying Cheong, D.M.   +4 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

The association between season and meteorological factors on clinical outcomes after fresh embryo transfer: a cohort study from Central Plains, China

Frontiers in Endocrinology
ObjectiveTo investigate whether seasonal variations and meteorological factors influence pregnancy outcomes in women undergoing in vitro fertilization/Intracytoplasmic sperm injection and embryo transfer(IVF/ICSI-ET) treatment.Materials and methodsWe ...
Hao Li, Xin Li, JinYu Li, YuMeng Ma, Gang Li   +4 more
doaj   +1 more source

FINAL OOCYTE MATURATION TRIGGER PROTOCOL IN POOR, NORMAL AND HIGH RESPONDERS: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS OF LIVE BIRTH RATES, LABORATORY OUTCOMES AND ADVERSE EFFECTS [PDF]

, 2023
Yusuf Beebeejaun, Timothy P. Copeland, Kuga Vigneswaran, Ippokratis Sarris, Sesh Kamal Sunkara   +4 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Comparison of clinical outcomes and perinatal outcomes between natural cycle and hormone replacement therapy of frozen-thawed embryo transfer in patients with regular menstruation: a propensity score-matched analysis

Frontiers in Endocrinology
PurposeTo investigate potential differences in pregnancy outcomes among patients with regular menstruation who underwent frozen-thawed embryo transfer using natural cycle (NC) or hormone replacement therapy (HRT).MethodsThis study retrospectively ...
Lin Sun, Beining Yin, Zhiyi Yao, Congli Zhang, Jinyu Li, Sichen Li, Yueyue Cui, Fang Wang, Wei Dai, Zhiqin Bu, Yile Zhang, Yile Zhang   +11 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The effect of transferring a low-quality embryo along with a high-quality embryo on the pregnancy outcome

Middle East Fertility Society Journal
Background Previous evidence suggests that low-quality embryos may send negative signals to the endometrium and affect the receptivity of the endometrium.
Xianju Huang, Xinle Lu, Xue Jiang, Ludan Chao, Xiao Wang   +4 more
doaj   +1 more source

DuoStim Shows Comparable Efficacy but Better Efficiency than Two Conventional Stimulations in Poor/Suboptimal Responders Undergoing Vitrified Oocyte Accumulation for PGT-A

Life
This study compared the DuoStim protocol with two conventional follicular phase stimulations for vitrified oocyte accumulation in poor-prognosis patients undergoing PGT-A.
Stefano Canosa, Alberto Revelli, Danilo Cimadomo, Alberto Vaiarelli, Gianluca Gennarelli, Daniela Guidetti, Andrea Roberto Carosso, Laura Rienzi, Filippo Maria Ubaldi, Francesca Bongioanni   +9 more
doaj   +1 more source