Results 61 to 70 of about 8,368,948 (289)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Frontiers in Endocrinology, 2021 BackgroundNo studies have been done to examine the efficacy of IVF and intrauterine insemination (IUI) for the treatment of young patients with unexplained infertility and low ovarian reserve, although it is becoming an increasingly significant ...
Yixuan Wu, Haiying Liu, Jianqiao Liu
doaj +1 more source
Cumulative live birth rate stratified according to serum AMH and antral follicle count (AFC).
, 2013 Panal (A) shows the association between serum AMH level and cumulative live birth rate from the fresh plus all frozen embryo transfer cycles combined, whereas Panal (B) shows that between AFC and cumulative live birth rate.
Estella Yee Lan Lau (405995) +5 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Down syndrome (DS) live birth rates.
, 2013 The Taiwanese DS live birth ratio dropped from 48.74% of all fetuses with DS in 2001 to 25.88% in 2006, when first-trimester DS screening was widely introduced.
Ming-Wei Lin (383487) +6 more
core +1 more source
Impact of a positive Chlamydia trachomatis serology on cumulative IVF live birth rate
, 2023 International audienceResearch questionDoes positive Chlamydia trachomatis serology have an impact on the cumulative live birth rate from IVF?DesignA retrospective matched cohort study compared women with positive Chlamydia trachomatis serology (group A)
Jeanne Perrin +11 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Outcomes and cost analysis of single-embryo transfer versus double-embryo transfer
Women's Health, 2023 Background: Studies had compared single-embryo transfer to double-embryo transfer with cleavage stage embryos and found that while single-embryo transfer was less costly, it was also associated with a lower live birth rate than double-embryo transfer.
Ker Yi Wong +10 more
doaj +1 more source
, 2018 Factors affecting the live birth rate after frozen-thawed blastocyst transfer: Logistic regression analysis of the risk.
Chloé Maignien (5076434) +7 more
core +1 more source