Results 61 to 70 of about 1,055,001 (304)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Influence of Borderline and Pathological Sperm Morphology on Pregnancy Outcomes following Intrauterine Insemination in Pregnant Women: A Retrospective Study [PDF]

International Journal of Fertility and Sterility
Background: The prognostic value of borderline and pathological sperm morphology (SM) in infertility treatmentremains unclear. This study aims to evaluate the potential impact of SM on clinical pregnancy outcomes followingintrauterine insemination (IUI ...
Roshan Nikbakht, Mahsa Afrough, Mahmoud Hashemitabar, Mojgan Barati, Sareh Amirzadeh, Narges Dibavand, Shokoofe Bazokarjoshaghani, Parvin Dorfeshan   +7 more
doaj   +1 more source

Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome [PDF]

, 2014
BACKGROUND Clomiphene is the current first-line infertility treatment in women with the polycystic ovary syndrome, but aromatase inhibitors, including letrozole, might result in better pregnancy outcomes. Full Text of Background...
Alvero, Ruben, Baker, Valerie, Barnhart, Kurt T., Bates, G. Wright, Bryzki, Robert, Casson, Peter, Christman, Gregory M., Coutifaris, Christos, Diamond, Michael, Eisenberg, Esther, Haisenleder, Daniel J., Huang, Hao, Krawetz, Stephen A., Legro, Richard S., Lucidi, Scott, Ohl, Dana, Santoro, Nanette, Schlaff, William D., Snyder, Peter, Trussell, J. C., Usadi, Rebecca, Yan, Qingshang, Zhang, Heping   +22 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The influence of female age on the cumulative live-birth rate of fresh cycles and subsequent frozen cycles using vitrified blastocysts in hyper-responders

Taiwanese Journal of Obstetrics & Gynecology, 2015
Objective: The aim of this research was to study the influence of female age on the cumulative live-birth rate of fresh and subsequent frozen cycles using vitrified blastocysts of the same cohort in hyper-responders.
Cheng-Hsuan Wu, Tsung-Hsien Lee, Hsiu-Hui Chen, Chung-I. Chen, Chun-Chia Huang, Maw-Sheng Lee   +5 more
doaj   +1 more source

Development speed of sibling embryo positively reflects live birth rate after fresh day 3 embryo transfer

Scientific Reports, 2023
The ability of sibling embryos to form blastocysts may reflect the developmental potential of the embryos that were transferred into the uterus. The purpose of the study was to investigate whether the development speed of sibling embryos positively ...
Xue Wang, Yaling Xiao, Yuanzheng Zhou, Hanbi Wang   +3 more
doaj   +1 more source

Kagera Regional and District Projections [PDF]

, 2006
This report presents population projections for the period 2003 to 2025 for the Kagera Region and its districts. The projections were made using a Cohort Component Method (Spectrum System), whereby three components responsible for population change ...
Aboud,, S.M., Amour, B. H., Chuma, A., Chuwa, A. A., Kaimu, A.M, Mbonile,, M., Mkai, P.B, Cletus, Naimani, Ngalinda, I, Ntimba, G. L.   +9 more
core  

Live birth rate and neonatal outcomes following interventional embolization of hydrosalpinx

Reproductive Health, 2022
Abstract Background Hydrosalpinx has a negative effect on the pregnancy outcomes of in vitro fertilization and embryo transfer (IVF-ET), and the pretreatment for hydrosalpinx play an important role in improving the outcomes of IVF-ET.
Haiyan Guo, Tong Du, Qifeng Lyu, Ling Wu, Weiran Chai, Qianqian Zhu   +5 more
openaire   +3 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Singida Regional and District Projections [PDF]

, 2006
\ud This report presents population projections for the period 2003 to 2025 for Singida Region and its districts. The projections were made using a Cohort Component Method (Spectrum System), whereby three components responsible for population change ...
Aboud, S.M., Amour, B. H., Chuma, Asha, Chuwa, A. A., Kaimu, A. M., Mbonile, M., Mkai, Cletus P.B, Naimani, G. M., Ngalinda, I., Ntimba, G. L.   +9 more
core