Results 71 to 80 of about 8,368,948 (289)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Pregnancy outcomes after fresh and frozen embryo transfer in women of advanced age and analysis of influencing factors: single-center experience

Frontiers in Endocrinology
ObjectiveTo investigate the differences in pregnancy outcomes between fresh embryo transfer (ET) and frozen embryo transfer (FET) in women of advanced age undergoing assisted reproductive technology (ART), and to provide evidence for optimizing embryo ...
Hongyan Jia, Jiahui Zhao, Xueqin Li, Ning Yang, Huaiyun Tang, Lisha Tang   +5 more
doaj   +1 more source

The influence of female age on the cumulative live-birth rate of fresh cycles and subsequent frozen cycles using vitrified blastocysts in hyper-responders

Taiwanese Journal of Obstetrics & Gynecology, 2015
Objective: The aim of this research was to study the influence of female age on the cumulative live-birth rate of fresh and subsequent frozen cycles using vitrified blastocysts of the same cohort in hyper-responders.
Cheng-Hsuan Wu, Tsung-Hsien Lee, Hsiu-Hui Chen, Chung-I. Chen, Chun-Chia Huang, Maw-Sheng Lee   +5 more
doaj   +1 more source

Usage and cost-effectiveness of elective oocyte freezing: a retrospective observational study

Reproductive Biology and Endocrinology, 2022
Background The previous model-based cost-effectiveness analyses regarding elective oocyte cryopreservation remained debatable, while the usage rate may influence the cost per live birth.
Ih-Jane Yang, Ming-Yih Wu, Kuang-Han Chao, Shin-Yi Wei, Yi-Yi Tsai, Ting-Chi Huang, Mei-Jou Chen, Shee-Uan Chen   +7 more
doaj   +1 more source

Annual changes in number of total live births, multiple births, and multiple birth rate in Korea (2009–2015).

, 2018
Annual changes in number of total live births, multiple births, and multiple birth rate in Korea (2009–2015).
In Yang Park (4246585), Jong Chul Shin (603994), Jeong Ha Wie (5635259), Hyun Sun Ko (5635256), Sae Kyung Choi (5635262), Yong-Gyu Park (579115)   +5 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Spatial clustering of areas with high rate of home delivery among women who had live birth in the last five years preceding 2019 EDHS.

, 2023
Spatial clustering of areas with high rate of home delivery among women who had live birth in the last five years preceding 2019 EDHS.
Dejene Edosa (13027302), Mukemil Awol (11309629), Kemal Jemal (11309620)   +2 more
core   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source