Results 81 to 90 of about 336,217 (299)

Cumulative live birth rates according to the number of oocytes retrieved following the “freeze-all” strategy

Reproductive Biology and Endocrinology, 2020
Background In recent years, some studies have shown that there is a positive association between the number of oocytes retrieved and the cumulative live birth rate (CLBR) after fresh and frozen cycles of one oocyte retrieval.
Zhonghua Zhao, Hao Shi, Jing Li, Yile Zhang, Caihong Chen, Yihong Guo   +5 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Population estimate, crude birth rate (CBR), live birth, maternal related deaths and hospital-based maternal mortality ratio (MMR) per year.

, 2019
Population estimate, crude birth rate (CBR), live birth, maternal related deaths and hospital-based maternal mortality ratio (MMR) per year.
Susan F. Rumisha (650281), Irene R. Mremi (5916842), Emanuel P. Lyimo (5916836), Veneranda M. Bwana (5217281), Leonard E. G. Mboera (527334)   +4 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Effect of post‐warming culture time on the live birth rate after frozen embryo transfer

, 2022
Purpose This study evaluated the influence of post‐warming culture time on the live birth rate in day‐3 and day‐5 frozen embryo transfer (FET) cycles. Methods This multicenter, retrospective cohort study was performed at IVFMD, My Duc Hospital and IVFMD ...
Tuong M. Ho MD, Huy H. Pham, Trinh M. Vu, Toan D. Pham, Chau H. Nguyen, Lan N. Vuong MD, PhD, Dung P. Nguyen, Anh H. Le   +7 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Observational cohort study exploring MediEmo smartphone application use, live birth, and in vitro fertilization treatment return rates

F&S Reports
Objective: To explore the associations between the use of the MediEmo smartphone application and in vitro fertilization (IVF) live birth and treatment return rates.
Isla F. Robertson, D.M., China R. Harrison, Ph.D., Richard D. Morey, Ph.D., Jacky Boivin, Ph.D., Ying Cheong, D.M.   +4 more
doaj   +1 more source

An assessment of the data quality for live births and infant deaths for the 1998-birth cohort, city of São Paulo, using information from SINASC and SIM [PDF]

In this article we use data from the 1998 birth-cohort from the City of São Paulo for live births and data on deaths from the same birth cohort that took place before the first year of life.
Carla Jorge Machado
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source