Results 51 to 60 of about 735,477 (263)

Cost-aware live migration of services in the cloud [PDF]

Proceedings of the 3rd Annual Haifa Experimental Systems Conference, 2010
Cloud computing is a paradigm in which dynamically scalable and often virtualized resources are provided as a service over the Internet. It is gaining popularity in a variety of domains such as web hosting, enterprise systems, and e-commerce sites.
David Breitgand, Gilad Kutiel, Danny Raz
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Distributed Edge Storage Systems: Proactive High-Availability Microservices with Live Migration and Rejuvenation Strategies

Mathematics
Mobile edge computing storage is increasingly used to support immersive services and Internet of Things applications that generate continuous real-time data streams.
Tuan Anh Nguyen, Damsub Lim, MinGi Kyung, Dugki Min   +3 more
doaj   +1 more source

Forced migration and education

Education in the North, 2020
This feature provides a brief account of the contemporary context of forced migration globally and the issues around education for refugees who have fled their home countries and live in exile.
Iryna Kushnir
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Exploring Live Cloud Migration on Amazon EC2 [PDF]

2017 IEEE 5th International Conference on Future Internet of Things and Cloud (FiCloud), 2017
Cloud users may decide to live migrate their virtual machines from a public cloud provider to another due to a lower cost or ceasing operations. Currently, it is not possible to install a second virtualization platform on public cloud infrastructure (IaaS) because nested virtualization and hardwareassisted virtualization are disabled by default.
Ibrahim Ejdayid A. Mansour, Hamid Bouchachia, Kendra M. L. Cooper   +2 more
openaire   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Analyzing Software Rejuvenation Techniques in a Virtualized System: Service Provider and User Views

IEEE Access, 2020
Virtualization technology has promoted the fast development and deployment of cloud computing, and is now becoming an enabler of Internet of Everything. Virtual machine monitor (VMM), playing a critical role in a virtualized system, is software and hence
Jing Bai, Xiaolin Chang, Fumio Machida, Kishor S. Trivedi, Zhen Han   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source