Results 91 to 100 of about 142,411 (300)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Livelihood Strategies And Livelihood System of Dryland Farmers

Agrisocionomics: Jurnal Sosial Ekonomi Pertanian
Dry land has great potential to support increased agricultural production, but its status is critical and farmers generally have weak capabilities (especially on capital). There is also a practice that destroys the environment and low technology adoption resulting in low income.
Rina Nuryati, Faqihuddin Faqihuddin, Cici Aulia Permata Bunda   +2 more
openaire   +1 more source

Impact assessment in the Sustainable Livelihood Framework

, 2012
The use of impact assessment can be characterised on a scale with ‘proving impact’ on one side and ‘improving practices’ on the other. Even though this is not an either/or scale, the two often do not combine automatically.
den Belder, Eefje, Burger, Kees, van Rijn, Fédes   +2 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Evaluation of Niassa Food and Livelihood Security Programme in Mozambique [PDF]

, 2007
The Food and Livelihood Security programme in southern Niassa supported about 7000 rural and poor farmer families to improve their productivity of food and cash crops, diversify crops and market access, build the capacity of farmers' organisations, and ...
Fombe, Honasio, Gardiner, Tom
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Livelihood Risk from HIV in Semi-Arid Tropics of Rural Andhra Pradesh [PDF]

This paper discusses the livelihood dynamics in the fragile landscape of the semi arid tropics (SAT) of Andhra Pradesh. SAT is home to the poorest of the poor who live in conditions of persistent drought, subsistence agriculture and poor access to ...
Gandhi, B. Valentine Joseph, Bantilan, M. Cynthia Serquina, Parthasarathy, Devanathan   +2 more
core   +2 more sources

Livelihood Diversification and Women Empowerment Through Self-Help Micro Credit Programme: Evidence from Jammu and Kashmir. [PDF]

In the paper an attempt has been made to analyze the process of livelihood diversification and women empowerment through women self-help groups (WSHGs) and micro credit and its impact under Integrated Watershed Development Project (IWDP), Hills-II, Jammu
Falendra K. Sudan
core