Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Correction: Employment quality and mental health in China under the policy of expanding jobs and benefiting people's livelihood: gender differences between low-quality employment and work-family values. [PDF]
Front Public HealthFrontiers Production Office.
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Climate change, livelihoods, gender and violence in Rukiga, Uganda: Intersections and pathways. [PDF]
PLOS Glob Public HealthMuhumuza R +6 more
europepmc +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Livlihood Diversification and Opinion Polls’ Analysis: Evidence From Tharparkar-Sindh (Pakistan)
In this paper attempt has been made: (i) to analyse the opinion poll of Tharis about livilihood and its diversifaction, (ii) to identify the livlihood available resources and attitute of Tharis to these resources.
Mahmud, Muhammad +3 more
core
Influence of Livelihood Strategies on Local People Perception Toward the Benefits and Cost of Community-Based Natural Resource Management: A Case of Burunge Wildlife Management Area, Tanzania. [PDF]
Ecol EvolKegamba JJ, Melembuki AS, Kyaruzi JJ.
europepmc +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Key emerging and conceptual issues in the development of the rural non-farm economy in developing countries and transition economies [PDF]
The rural non-farm economy (RNFE) is of interest to governments, multilateral donor organisations, non-governmental organisations (NGOs) and development practitioners because of its increasing prevalence in both developing and transition economies.
Junior Davis, Dirk Bezemer
core
Navigating access barriers: Strategies for Syrian refugees confronting healthcare challenges in Jordan - A qualitative approach. [PDF]
PLOS Glob Public HealthAbu-Siam IK +4 more
europepmc +1 more source